AMPA
IUPAC name

2-amino-3-(5-methyl-3-oxo-1,2-
oxazol-4-yl)propanoic acid
Identifiers
CAS number 77521-29-0 N
PubChem 1221
ChemSpider 1184 YesY
DrugBank DB02057
KEGG C11033 YesY
MeSH AMPA
ChEMBL CHEMBL276815 N
Jmol-3D images Image 1
Properties
Molecular formula C7H10N2O4
Molar mass 186.17 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

AMPA (2-amino-3-(5-methyl-3-oxo-1,2- oxazol-4-yl)propanoic acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.[1]

There are two types of Ionotropic glutamate receptors that are ligand gated ion channels whose agonists include AMPA, Kainate and NMDA. In the synapse, these two classes of receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions.[2] AMPA generates fast excitatory postsynaptic potentials (EPSP).[1] AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na+ and K+ and therefore have an equilibrium potential near 0 mV.

References [link]

  1. ^ a b Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed.. Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7. 
  2. ^ Dinh, L; Nguyen T, Salgado H, Atzori M (2009). "Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat". Neurochem Res 34 (11): 1896–906. DOI:10.1007/s11064-009-9966-z. PMID 19357950. 

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AMPA (disambiguation)

AMPA is a chemical compound that is a specific agonist for the AMPA receptor.

AMPA may also refer to:

  • American Military Partner Association, a U.S. LGBT advocacy and support group
  • Aminomethylphosphonic acid, a degradation product of glyphosate


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    God Only Knows

    by: Amb

    Otis:
    Did I really take her and keep her with me?
    Cover her face up so she couldn't breathe?
    Cut her eyeballs out so she couldn't see?
    I still feel like she is looking at me.
    Brought her to the basement and took off her clothes
    Did I do the right thing?
    God only knows!
    Chorus x 4:
    Maybe I was only wondering if I could open up your body
    Take your heart out and consume
    ("God only knows!" throughout chorus)
    Otis:
    Am I really like this? Is this really me?
    Am I really the person I want to be?
    Is it this life that has created me?
    Am I a product of society?
    Did I really eat pills cause everything's fucked?!
    Can I fall asleep and just never wake up?!!
    Chorus x 4:
    Maybe I was only wondering if I could open up your body
    Take your heart out and consume




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