AMG-41

AMG-41 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopropyl group on the C1'-position of the C3-alkyl side chain. AMG-41 is a potent agonist at both CB₁ and CB₂, with a K_i of 0.4nM at CB₁ vs 0.9nM at CB₂.

References

AMG

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AMG-3

AMG-3 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC substituted with a dithiolane group on the 3-position side chain. AMG-3 is a potent agonist at both CB₁ and CB₂ receptors with a K_i of 0.32nM at CB₁ and 0.52nM at CB₂, and its particularly high binding affinity has led to it being used as a template for further structural development of novel cannabinoid drugs. It has sedative and analgesic effects, with analgesia lasting for up to 36 hours after administration.

References

AMG-36

AMG-36 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a K_i of 0.4nM at CB₁ vs 1.9nM at CB₂.

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