Amatuni (Armenian: Ամատունի) is an ancient Armenian noble family, known from the 4th century in the canton of Artaz, between lakes Van and Urmia, with its center at Shavarshan (latter-day Maku), and subsequently also at Aragatsotn, west of Lake Sevan, with the residence at Oshakan.
The Amatuni who was of Caspio-Median or Matianian-Mannaean origin, is given a specious Jewish ancestry by the early Armenian tradition (Moses of Chorene 2.57). Their forefather's name Manue suggests a connection with royal house of Adiabene.