ALD-52

ALD-52, also known as 1-acetyl-LSD, is a chemical analogue of lysergic acid diethylamide (LSD). It was originally discovered by Albert Hofmann but was not widely studied until the rise in popularity of psychedelics in the 1960s.

Effects

In Entry 26 of his compendium TiHKAL, which discussed LSD, Shulgin touched briefly on the subject of ALD-52. His writings are vague, second hand accounts, saying doses in the 50-175 µg range have resulted in various conclusions. He found that there was less visual distortion than with LSD and it seemed to produce less anxiety and tenseness and that it was somewhat less potent. Another informant claimed it was more effective in increasing blood pressure. Yet another informant could not tell them apart.

Safety

In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 is listed as having a lower (approximately ¹/₅) intravenous toxicity (in rabbits), a lower (approximately ¹/₈) pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD.