Alad

Alad (Persian: اعلاڈ‎‎, also Romanized as Āʿlāɖ; also known as A‘lā) is a village in Seydun-e Jonubi Rural District, Seydun District, Bagh-e Malek County, Khuzestan Province, Iran. At the 2006 census, its population was 735, in 143 families.

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ALAD

Delta-aminolevulinic acid dehydratase is an enzyme that in humans is encoded by the ALAD gene.

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead, beginning at blood lead levels that were once considered to be safe (<10 μg/dL) and continuing to correlate negatively across the range from 5 to 95 μg/dL. Inhibition of ALAD by lead leads to anemia primarily because it both inhibits heme synthesis and shortenis the lifespan of circulating red blood cells, but also by stimulating the excessive production of the hormone erythropoietin, leading to inadequate maturation of red cells from their progenitors. A defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternatively spliced transcript variants encoding different isoforms have been identified.