AKT1
RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) domains. It is commonly referred to as PKB, or by both names as "Akt/PKB".
Function
The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mice lacking Akt1 display a 25% reduction in body mass, indicating that Akt1 is critical for transmitting growth-promoting signals, most likely via the IGF1 receptor. Mice lacking Akt1 are also resistant to cancer: They experience considerable delay in tumor growth initiated by the large T antigen or the Neu oncogene. A single-nucleotide polymorphism in this gene causes Proteus syndrome.
Podcasts:
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by Soundtracks (other tracks) soundtrack
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by Uriah Heep
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by Akon
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by Band
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by Kris Allen
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by Jarboe
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by S Club 8
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by D.A.D.
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by S Club Juniors
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by Light in the Piazza Soundtrack
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by Miss Saigon Soundtrack
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by Cheek
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by Carl Wayne
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by John Barrowman
Why God Why
by: Soundtracks (other tracks) soundtrack(KIM leads CHRIS out of the Club, and into a tiny cubicle, which has in it
only a bed, a table, and a small window overlooking the moonlit city.
Later in the night, CHRIS is dressed and standing at the window. KIM is
asleep. Outside, Saigon still bustles.)
CHRIS
why does Saigon never sleep at night?
why does this girl smell of orange trees?
how can I feel good when nothing's right?
why is she cool when there is no breeze?
Vietnam
you don't give answers, do you friend?
just questions that don't ever end
why God? Why today?
I'm all through here, on my way
there's nothing left here that I'll miss
why send me now a night like this?
who is the girl in this rusty bed?
why am I back in a filthy room?
why is her voice ringing in my head?
why am I high on her cheap perfume?
Vietnam
hey look I mean you no offense
but why does nothing here make sense?
why God? Show your hand
why can't one guy understand?
I've been with girls who knew much more
I never felt confused before
why me? What's your plan?
I can't help her, no one can
I liked my mem'ries as they were
but now I'll leave rememb'ring her
(CHRIS leaves some money on a table and goes out into the street. CHRIS
is accosted by Vietnamese who beg for help leaving the country. He
pushes them.)
when I went home before
no one talked of the war
what they knew from TV
didn't have a thing to do with me
I went back and re-upped
sure Saigon is corrupt
it felt better to be
here driving for the embassy
'cause here if you can pull a string
a guy like me lives like a king
just as long as you don't believe anything
(CHRIS stops, then goes back into KIM'S room.)
why God? Why this face?
why such beauty in this place?
I liked my mem'ries as they were
but now I'll leave rememb'ring her
just her