Aichi Prefecture

Aichi Prefecture (愛知県, Aichi-ken) is a prefecture of Japan located in the Chūbu region. The region of Aichi is also known as the Tōkai region. The capital is Nagoya. It is the focus of the Chūkyō Metropolitan Area.

History

Originally, the region was divided into the two provinces of Owari and Mikawa. After the Meiji Restoration, Owari and Mikawa were united into a single entity. In 1871, after the abolition of the han system, Owari, with the exception of the Chita Peninsula, was established as Nagoya Prefecture, while Mikawa combined with the Chita Peninsula and formed Nukata Prefecture. Nagoya Prefecture was renamed to Aichi Prefecture in April 1872, and was united with Nukata Prefecture on November 27 of the same year.

The government of Aichi Prefecture is located in the Aichi Prefectural Government Office in Nagoya, which is the old capital of Owari.

The Expo 2005 World Exposition was held in Seto and Nagakute.

Etymology

In the third volume of the Man'yōshū there is a poem by Takechi Kurohito that reads: "The cry of the crane, calling to Sakurada; it sounds like the tide, draining from Ayuchi flats, hearing the crane cry". Ayuchi is the original form of the name Aichi, and the Fujimae tidal flat is all that remains of the earlier Ayuchi-gata. It is now a protected area.

Aichi (disambiguation)

Aichi Prefecture is a prefecture of Japan in the Chūbu region.

Aichi may also refer to:

See also

Aichi (surname)

Aichi (written: 愛知) is a Japanese surname. Notable people with the surname include:

Complement component 4

Complement component 4 is a protein involved in the complement system.

It is cleaved into proteins 4a and 4b; 4b can be further cleaved into 4c and 4d.

Clinical significance

It is responsible for the Chido Rodgers blood group system.

C4d has been identified as a biomarker for systemic lupus erythematosus.

The gene that codes for C4 is being investigated for the role it may play in schizophrenia risk and development.

References

C4A

Complement C4-A is a protein that in humans is encoded by the C4A gene.

Function

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.

See also

References

Further reading