AGN-2979

AGN-2979 is a tryptophan hydroxylase inhibitor. It shows antidepressant properties in rodent models of depression.

References

AGN

AGN may refer to:

Agnes (name)

Agnes is a female given name, which derives from the Greek name Ἁγνὴ hagnē, meaning "pure" or "holy". The name passed to Italian as Agnese, to Portuguese as Inês, and to Spanish, as Inés.

It was the name of a popular Christian saint, Saint Agnes of Rome, a fact which encouraged the wide use of the name. Agnes was the third most popular name for women in the English speaking world for more than 400 years. Its medieval pronunciation was "Annis," and its usage and many of its forms coincided with the equally popular English name Anne, a name related in medieval and Elizabethan times to 'Agnes', though Anne/Ann/Anna are derived from the Hebrew Hannah ('God favored me') rather than the Greek. It remained a widely used name throughout the 1960s in the United States. It was last ranked among the top 1,000 names for American girls during that decade. The peak of its popularity was between 1900 and 1920, when it was among the top 50 names for American girls. The Swedish version of the name was the 16th most popular name for girls born in Poland in 2007, having risen as high as third place in Sweden and Poland in 2006. It was also ranked among the top 100 names for girls in Hungary in 2005. Neža, a Slovene short form, was ranked among the top 10 names for girls born in Slovenia in 2008. French forms Inès and Ines were both ranked among the top 10 names for girls born in Brussels, Belgium in 2008.

Silver azide

Silver azide is the chemical compound with the formula AgN₃. This colorless solid is a well-known explosive.

Structure and chemistry

Silver azide can be prepared by treating an aqueous solution of silver nitrate with sodium azide. The silver azide precipitates as a white solid, leaving sodium nitrate in solution.

X-ray crystallography shows that AgN₃ is a coordination polymer with square planar Ag⁺ coordinated by four azide ligands. Correspondingly, each end of each azide ligand is connected to a pair of Ag⁺ centers. The structure consists of two-dimensional AgN₃ layers stacked one on top of the other, with weaker Ag–N bonds between layers. The coordination of Ag⁺ can alternatively be described as highly distorted 4 + 2 octahedral, the two more distant nitrogen atoms being part of the layers above and below.

In its most characteristic reaction, the solid decomposes explosively, releasing nitrogen gas:

The first step in this decomposition is the production of free electrons and azide radicals; thus the reaction rate is increased by the addition of semiconducting oxides. Pure silver azide explodes at 340 °C, but the presence of impurities lowers this down to 270 °C. This reaction has a lower activation energy and initial delay than the corresponding decomposition of lead azide.