Aggrecan
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.
Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing.
Structure
Aggrecan is a high molecular weight (1x106 < M < 3x106) proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate glycosaminoglycan (GAG) chains are attached to an extended protein core.
Aggrecan has a molecular mass >2,500 kDa. The core protein (210–250 kDa) has 100–150 GAG chains attached to it.
Aggrecan consists of two globular structural domains (G1 and G2) at the N-terminal end and one globular domain (G3) at the C-terminal end, separated by a large extended domain (CS) heavily modified with GAGs. (N-G1-G2-CS-G3-C) The two main modifier moieties are themselves arranged into distinct regions, a chondroitin sulfate and a keratan sulfate region.
Podcasts:
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by Buck O Nine
You Go You're Gone
by: Buck O NineWell, Tommy stepped away
From the world for awhile
He only left a picture
Of a seventh grade smile
Well, he got caught in between
A mother's lost hope
And a father's lost dream
A head of ideas
That don't mean anything
That don't mean anything
Well, Tommy had a problem
With being alone
He spent everyday
Of his life on his own
But there's no one to blame
It's hard to keep friends
When you keep moving away
The cards and letters
They don't mean anything
They don't mean anything
And when you go, you go
You go, you go
When you're gone, you're gone
You're gone, you're gone
And if you feel you can't go on
You can always come home
You can always come home
You can always come home to me
Tommy stepped away
From the world for awhile
His first few steps
It felt like a mile
They never could believe
He said good-bye
And they just watched him leave
All the things he knew
Don't mean anything
They don't mean anything
And when you go, you go
You go, you go
When you're gone, you're gone
You're gone, you're gone
And if you feel you can't go on
You can always come home
You can always come home
You can always come home to me
And if you go too far
You might never come back
And I might go too far
But I won't ever some back
And when you go, I'll wait for you
And when you go, I'll be there too
And when you go, you go
You go, you go
When you're gone, you're gone
You're gone, you're gone
And if you feel you can't go on