Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene.
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.
SUMO4 has been shown to interact with IκBα.
Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene.
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
SUMO2 has been shown to interact with TRIM63 and c21orf59.
Small ubiquitin-related modifier 3 is a protein that in humans is encoded by the SUMO3 gene.
SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002).[supplied by OMIM]
SUMO3 has been shown to interact with ARNTL and Thymine-DNA glycosylase.
Africa is an epic poem in Latin hexameters by the 14th century Italian poet Petrarch (Francesco Petrarca). It tells the story of the Second Punic War, in which the Carthaginian general Hannibal invaded Italy, but Roman forces were eventually victorious after an invasion of north Africa led by Publius Cornelius Scipio Africanus, the epic poem's hero.
Africa and De viris illustribus were partially inspired by Petrarch's visit to Rome in 1337. According to Bergin and Wilson (p. ix). It seems very likely that the inspirational vision of the Eternal City must have been the immediate spur to the design of the Africa and probably De viris illustribus as well. After returning from his grand tour, the first sections of Africa were written in the valley of Vaucluse. Petrarch recalls
The fact that he abandoned it early on is not entirely correct since it was far along when he received two invitations (from Rome and from Paris) in September 1340 each asking him to accept the crown as poet laureate. A preliminary form of the poem was completed in time for the laurel coronation April 8, 1341 (Easter Sunday).
Africa is 2009 Perpetuum Jazzile album. By large most successful song from the album is a capella version of Toto's "Africa", the performance video of which has received more than 15 million YouTube views since its publishing in May 2009 until September 2013.
Africa (Latin: Africa) was a Roman goddess worshipped in North Africa.
Pliny the Elder, in his book Natural Story, wrote that nobody in Africa (North Africa) embarked upon anything without first calling for funding from the goddess.
She is normally depicted with a skinned elephant on her head and a horn of fertility in her hands, while sitting in front of a modius of wheat. The totemic objects that are linked with her are scorpios, bows and arrow quivers.
She is portrayed on some coins, carved stones, and mosaics in Roman Africa; some are in the El Djem museum.
Free: The Future of a Radical Price is the second book written by Chris Anderson, Editor in chief of Wired magazine. The book was published on July 7, 2009 by Hyperion. He is also the author of The Long Tail, published in 2006.
Free follows a thread from the previous work. It examines the rise of pricing models which give products and services to customers for free, often as a strategy for attracting users and up-selling some of them to a premium level. That class of model has become widely referred to as "freemium" and has become very popular for a variety of digital products and services.
Free was released in the United States on July 7, 2009, though the night before, on his blog, Chris Anderson posted a browser readable version of the book and the unabridged audiobook version. Anderson generated controversy for plagiarizing content from the online encyclopedia Wikipedia in Free. Anderson responded to the claim on his The Long Tail blog, stating that there were disagreements between him and the publisher over accurate citation of Wikipedia due to the changing nature of its content, leading him to integrate footnotes into the text. Also on his blog, he took full responsibility for the mistakes and noted that the digital editions of Free were corrected. The notes and sources were later provided as a download on his blog.
Juughh... This phone call... I gonna see around, what a this phone call
Uhhhhhhh, Africa, where are you now? Uhhhhhhh, Africa, where are you now?
Well, I look to the east to found you, look to the west to found you, now I can´t ..........
Or no more rule, to ........., hot no fool to love me now ...........
Uhhhhhhhuuuhhhuuuu, África!!!! Uhhhhhhhuuuhhhuuuu, África!!!!
Don´t come around to Babylon I no wanna, want to show me were ...........
Don´t want no ........... Don´t want no ...................... in África