Fibroblast activation protein alpha is a 170 kDa melanoma membrane-bound gelatinase, protein that in humans is encoded by the FAP gene.
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
FAP, also known as seprase, belongs to the clan SC proteases and is a member of the S9B prolyl oligopeptidase subfamily. Other members of the S9B subfamily are DPPIV, DPP8 and DPP9. FAP is most closely related to DPPIV and they share about 50% of their amino acids.
FAP is catalytically active as a 170kD dimer and has dipeptidase and gelatinase activity. Its gelatinase activity requires a glycine in P2 position.
FAP 1117 was the predecessor of the latest FAP military truck version, FAP 1118. This is an all-terrain vehicle developed by VTI and scheduled for production by FAP factory in Priboj. It was not introduced in serial production, being only prototype, while it's lightly improved successor, FAP 1118 is in full serial production.
It is designed for transport of personnel, weapons and material of up to 4t gross weight, as well as for towing of artillery pieces and trailers. Equipped with all-wheel drive, locking of all differentials and powerful diesel engine, the vehicle is able to negotiate cross-country gradients of 60%. Central regulation of tire pressure assures high mobility over soft soil and its well thought out body geometry enables easy negotiating of natural and man-made obstacles such as trenches, railway embankments, escarps etc.
FAP 2026 is a general purpose off-road lorry made by Serbian vehicle manufacturer Fabrika automobila Priboj (FAP). The six-wheel drive lorry is designed for transport of personnel, weapons and material up to 6 tons of total weight, as for traction of weapons and trailer up to 7.2 tons of weight for the needs of the Yugoslav People's Army.
During 1965 the Department for Traffic of Federal Secretariat of People's Defense has formed work group with task to analyzes the unarmored vehicles of Yugoslav People's Army. the result of work group was the Study of non-combat vehicles and trailers in use with Yugoslav People's Army. The inferences of study were adopted by Main Military Technical Council in 1966. The study has concluded that there are 129 different vehicle marks in 320 types in service. A decision was made to reduce number of different vehicle marks in service by development of five vehicle classes: 0,75 tons 4x4 off-road vehicle, 1,5 tons 4x4 off-road truck, 3 tons 6x6 off-road truck, 6 tons 6x6 off-road truck and 9 tons 8x8 heavy off-road truck.
Adrian is a form of the Latin given name Adrianus or Hadrianus. Its ultimate origin is most likely via the former river Adria from the Venetic and Illyrian word adur, meaning 'sea' or 'water'. The Adria was until the 8th century BC the main channel of the Po River into the Adriatic Sea but ceased to exist before the 1st century BC. Hecataeus of Miletus (c.550 - c.476 BC) asserted that both the Etruscan harbor city of Adria and the Adriatic Sea had been named after it. Emperor Hadrian's family was named after the city or region of Adria/Hadria, now Atri, in Picenum, which most likely started as an Etruscan or Greek colony of the older harbor city of the same name.
Several saints and six popes have borne this name, including the only English pope, Adrian IV, and the only Dutch pope, Adrian VI. As an English name, it has been in use since the Middle Ages though it was not popular until modern times.
Adrian Ma, (born February 18, 1997) usually known just as Adrian or Popstar Adrian, is an American professional League of Legends player who currently plays support for Immortals of the North American League of Legends Championship Series. He graduated high school early at age 17 to attend the first varsity college eSports team in the world, the program at Robert Morris University Illinois. Adrian has also played for LMQ and Team Impulse.
On July 18, 2015 he temporarily stepped down from his role on the starting roster of Team Impulse.
In December newly formed NA LCS team Immortals announced they had acquired Adrian.
Adrian is a masculine given name.
Adrian may also refer to: