Adrenalina

Adrenalina may refer to:

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Adrenalina (Wisin song)

"Adrenalina" (English: "Adrenaline") is a song recorded by Puerto Rican singers Wisin, Ricky Martin and Jennifer Lopez. It was written by Lopez, Martin, Wisin, José Torres and Carlos E. Ortiz. It was released as the second single from Wisin's second studio album El Regreso del Sobreviviente. It received a nomination for the Billboard Latin Music Award for Latin Rhythm Airplay Song of the Year in 2015.

Background and release

On October 30, 2012, it was revealed that Jennifer Lopez, Ricky Martin and Wisin had recorded on a song together entitled "Adrenalina". Wisin & Yandel had previously collaborated with Jennifer Lopez on "Follow the Leader" (2012), the lead single from their ninth studio album Líderes (2012), and with Ricky Martin on "Frío", the third single from his ninth studio album Música + Alma + Sexo (2011).

Music video

The music video was filmed in February 2014 in Miami and directed by Jessy Terrero. There are two versions: one for the Spanish version and one for the Spanglish version. The video for the Spanish version premiered on March 3, 2014 on Vevo and got ten million views in one week. The music video was nominated for Video of the Year at the Lo Nuestro Awards of 2015. The Martin video for the Spanglish Version premiered on April 10, 2014 on Vevo. Another video was created by Univision for their 2014 FIFA World Cup coverage.

Adrenalina (Finley album)

Adrenalina is Finley's second studio album. It was released on June 15, 2007 by EMI.

They have already been released three singles from this CD: Adrenalina, Domani and Questo sono io. Niente da perdere was played for the first time as anticipating the album Adrenalina at the MTV TRL Awards 2007, which took place in Milan, on April 14, in Piazza Duomo, followed by a medley of Fumo e cenere, Tutto è possibile and Diventerai una star. During the Tour On TRL, in Bari and in Roma they played the song Domani, the second single from the album. On Friday 28 September 2007 for the first time it was sent their second exclusive video of Domani in the television broadcast TRL. In addition, MTV choose Finley with their video of Domani to open from 1 October 2007 Pulse, a new digital channel. On 1 December 2007 they performed live to the Kids' Choice Awards their third single, Questo sono io.

Track listing

All songs written and composed by Marco Pedretti, Carmine Ruggiero, Stefano Mantegazza and Danilo Calvio. 

MDM

MDM may refer to:

In business

In entertainment

In science and technology

Mdm2

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation.

Discovery and expression in tumor cells

The murine double minute (mdm2) oncogene, which codes for the Mdm2 protein, was originally cloned, along with two other genes (mdm1 and mdm3) from the transformed mouse cell line 3T3-DM. Mdm2 overexpression, in cooperation with oncogenic Ras, promotes transformation of primary rodent fibroblasts, and mdm2 expression led to tumor formation in nude mice. The human homologue of this protein was later identified and is sometimes called Hdm2. Further supporting the role of mdm2 as an oncogene, several human tumor types have been shown to have increased levels of Mdm2, including soft tissue sarcomas and osteosarcomas as well as breast tumors. The MDM2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. MDM2 supports the Polycomb-mediated repression of lineage-specific genes, independent of p53. MDM2 depletion in the absence of p53 promoted the differentiation of human mesenchymal stem cells and diminished clonogenic survival of cancer cells. Most of the MDM2-controlled genes also responded to the inactivation of the Polycomb Repressor Complex 2 (PRC2) and its catalytic component EZH2. MDM2 physically associated with EZH2 on chromatin, enhancing the trimethylation of histone 3 at lysine 27 and the ubiquitination of histone 2A at lysine 119 (H2AK119) at its target genes. Removing MDM2 simultaneously with the H2AK119 E3 ligase Ring1B/RNF2 further induced these genes and synthetically arrested cell proliferation.

MDM4

Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.

Function

The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2

Interactions

MDM4 has been shown to interact with E2F1,Mdm2 and P53.

References

Further reading