Adisadel College is an Anglican school for boys in Cape Coast, Ghana, modelled on the English public school.
Adisadel was established in 1910 in a building at Topp Yard, near Christ Church and Cape Coast Castle. It began with 29 boys, but in 1935 it had about 200. The school buildings were extended in 1950 by Maxwell Fry and Jane Drew. At the time of the Golden Jubilee in 1960, enrolment had gone up to 545. When the school celebrated its centenary in 2010 there were over 1500 boys (all boarders) and 93 teachers.
The school's Founder was Temple Hamlyn, Anglican Bishop of Accra. His purpose was to provide a grammar school for sons of Anglican parents, in particular a training ground for Church personnel.
The School is the second-oldest secondary school in Ghana, and claims to be one of the most famous institutions of learning in sub-Saharan Africa. The first secondary school to be established in Ghana was Mfantsipim School, also in Cape Coast, which was founded by the Methodist Church in 1876. It currently has 10 houses, the most recent being Thomas Jonah House, built in 1997.