Latest News for: ads cft
- 1
(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane (β-CFT, WIN 35,428) is a stimulant drug used in scientific research. CFT is a phenyltropane based dopamine reuptake inhibitor and is structurally derived from cocaine. It is around 3-10x more potent than cocaine and lasts around 7 times longer based on animal studies. While the naphthalenedisulfonate salt is the most commonly used form in scientific research due to its high solubility in water, the free base and hydrochloride salts are known compounds and can also be produced. The tartrate is another salt form that is reported.
CFT was first reported by Clarke and co-workers in 1973. This drug is known to function as a "positive reinforcer" (although it is less likely to be self-administered by rhesus monkeys than cocaine). Tritiated CFT is frequently used to map binding of novel ligands to the DAT, although the drug also has some SERT affinity.
Radiolabelled forms of CFT have been used in humans and animals to map the distribution of dopamine transporters in the brain. CFT was found to be particularly useful for this application as a normal fluorine atom can be substituted with the radioactive isotope 18F which is widely used in Positron emission tomography. Another radioisotope-substituted analog [11C]WIN 35,428 (where the carbon atom of either the N-methyl group, or the methyl from the 2-carbomethoxy group of CFT, has been replaced with 11C) is now more commonly used for this application, as it is quicker and easier in practice to make radiolabelled CFT by methylating nor-CFT or 2-desmethyl-CFT than by reacting methylecgonidine with parafluorophenylmagnesium bromide, and also avoids the requirement for a licence to work with the restricted precursor ecgonine.
Pelican Airport, (TC LID: CFT8), is located 31 km (19 mi) east of Wabasca, Alberta, Canada.
It is a private airport that serves the Wabasca oil field.
Finlayson Lake Airport (TC LID: CFT3) is located adjacent to the south side of the Robert Campbell Highway near Ross River, Yukon, Canada.
HD 220105 is a star in the northern constellation of Andromeda.
HD 33203 is double star in the northern constellation of Auriga. It includes a supergiant star with a stellar classification of B2II. The two components have an angular separation of 1.617″ along a position angle of 222.1°.
51 Aquilae (abbreviated 51 Aql) is a star in the equatorial constellation of Aquila. 51 Aquilae is its Flamsteed designation. It has an apparent visual magnitude of 5.39, which means it is faintly visible to the naked eye. Based upon an annual parallax shift of 35.88 mas, the distance to this star is around 90.9 light-years (27.9 parsecs).
This is an F-type main sequence star with a stellar classification of F5 V Fe-1 CH-0.7; where the 'Fe-1' and 'CH-0.7' represent abundance deficiencies of iron and the molecule CN, respectively. It is about 1.6 billion years old and is spinning relatively quickly with a projected rotational velocity of 77.5 km/s. The outer atmosphere has an effective temperature of 6,812 K, giving it the yellow-white hue characteristic of an F-type star.
