Active site

In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of residues that form temporary bonds with the substrate (binding site) and residues that catalyse a reaction of that substrate (catalytic site). The active site is usually a groove or pocket of the enzyme which can be located in a deep tunnel within the enzyme, or between the interfaces of multimeric enzymes. An active site can catalyse a reaction repeatedly as its residues are not altered at the end of the reaction (they may change during the reaction, but are regenerated by the end).

Binding site

Usually, an enzyme molecule has only one active site, and the active site fits with one specific type of substrate. An active site contains a binding site that binds the substrate and orients it for catalysis. Residues in the binding site form hydrogen bonds, hydrophobic interactions, or temporary covalent interactions (van der Waals) with the substrate to make an enzyme-substrate complex. In order to function, the active site needs to be in a specific conformation and so denaturation of the protein by high temperatures or extreme pH values will destroy its catalytic activity. A tighter fit between an active site and the substrate molecule is believed to increase efficiency of a reaction. Most enzymes have deeply buried active sites, which can be accessed by a substrate via access channels.

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Activist

by: Sepultura

Our pulse to resist
Moves our cultural resistance
I'm living this life
Inside a civil tribe demised
Improve my old mind
Breaking all rules, absorbing what I may find
Our manner to protect
Destroys what's left for protection
Believing in symbols
The church will fool our souls
Prove you my role
Acting against undesired control
Don't fear your left
Don't trust your right
Activist
Our way of seeing progress
Makes us walk towards repression
Disturbing our peace
In the name of self defense
Being felt by all
Our violent taste for the humans fall
Don't fear your left
Don't trust your right




Latest News for: active site

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The Biden-era regulation, which took effect in May 2024, essentially requires owners of inactive coal ash disposal sites to follow the same clean-up rules as active dump sites, closing a loophole that had long frustrated environmentalists.

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Austin American-Statesman 24 Mar 2025
By now, you know about the Gault Site north of Austin, which has produced an enormous array of archaeological evidence about human activity in Central Texas from as long as 20,000 years ago ... activity.

BYDFi Official Statement: Beware of Phishing Sites and Online Scam Risks

Finance Magnates 24 Mar 2025
The BYDFi team has reported that they recently identified multiple phishing websites and fraudulent activities targeting its users ... Beware of the Potential Threats of Phishing Sites ... Key Measures to Prevent Phishing Sites.

Shady website is exposed as disturbing list emerges of military-grade firearms 'Aussie gangsters' can buy ...

The Daily Mail 24 Mar 2025
'The public is reminded that websites claiming to sell illegal items are generally scam sites.'. Queensland Police said it is investigating the site and that it 'urges the public to remain vigilant against online scams and fraudulent activities'.

Six months after Helene, recovery efforts for endangered woodpeckers remain a priority

The Augusta Chronicle 24 Mar 2025
“The areas with the RCW cluster sites and the areas they use to forage, damage was variable,” said Burnam ... Within two weeks of the storm, we were all able to work together to clear the roads to access the cluster sites.

Exercise to grant ownership rights to lal dora occupants continues: Punjab minister Hardip Singh Mundian

The Times of India 24 Mar 2025
... or by lifting water from the dam.Bathinda lakes to be developedPunjab is actively undertaking conservation and restoration work on various historical monuments and tourist sites across the state.

DOGE Goons Tried to Fire Emergency ICU Doctors at NIH Hospital

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... medical personnel in the intensive care unit at the NIH Clinical Center in Bethesda, Maryland, which doubles as an active hospital and research site.

Seaside paradise village split between locals and holiday let owners over 'noisy' fishermen | Daily ...

The Daily Mail 24 Mar 2025
The site now faces enforcement action, which could impose restrictions on what activity takes place there and make it commercially unviable ... to the application and documents the changes to the site.

Anglo Asian mines first ore from Gilar

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AAZ) said on Monday it had mined the first ore from Gilar, its new underground operation at the Gedabek site in Azerbaijan ... According to , Azerbaijan has been actively developing its hydrocarbon and mining industries.

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The Times of India 24 Mar 2025
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DDA issued an expression of interest on Sunday for the disposal of land there after inviting reputed players with at least 10 years of experience to establish and operate the sports stadium and run ...

CM orders strict action in cases of crime against women

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The meeting, held via video conferencing, focused on security, public services, and governance ... He emphasised women’s security at religious sites, patrolling enhancements, active PRV 112, and preventing vehicle overloading ... See More ... See Less ....

Scientists engineer starfish cells to shape-shift in response to light

Phys Dot Org 24 Mar 2025
"By revealing how a light-activated switch can ... They found that when they aimed the light in specific points, the GEF enzyme became activated and recruited Rho protein to the light-targeted sites.

Development of riverfront road under way in Speaker’s constituency

The Times of India 24 Mar 2025
Mangaluru ... The construction activities are currently under way at multiple sites along the stretch. The completion of the entire project will require additional time. The total project cost is estimated at Rs 160 crore ... .
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