ABT-418
ABT-418 is a drug developed by Abbott, that has nootropic, neuroprotective and anxiolytic effects, and has been researched for treatment of both Alzheimer's disease and ADHD. It acts as an agonist at neural nicotinic acetylcholine receptors, subtype-selective binding with high affinity to the α4β2, α7/5-HT3, and α2β2nicotinic acetylcholine receptors but not the α3β4 subtype familiar to nicotine. ABT-418 was reasonably effective for both applications and fairly well tolerated, but produced some side effects, principally nausea, and it is unclear whether ABT-418 itself will proceed to clinical development or if another similar drug will be used instead.
See also
References
Abt
Abt or ABT may refer to:
See also
9423 Abt
9423 Abt, provisional designation 1996 AT7, is a stony asteroid from the middle region of the asteroid belt, about 13 kilometers in diameter. It was discovered by the U.S. Spacewatch project of the University of Arizona at Kitt Peak National Observatory, on 12 January 1996.
The S-type asteroid orbits the Sun at a distance of 2.4–3.0 AU once every 4 years and 5 months (1,614 days). Its orbit shows an eccentricity of 0.10 and is tilted by 9 degrees to the plane of the ecliptic. A photometric light-curve observation at Hunters Hill Observatory, Australia, in 2006 gave it a rotation period of 7000328100000000000♠3.281±0.005 hours with a brightness amplitude of 0.30 in magnitude. A second light-curve analysis took place at the Palomar Transient Factory survey in 2012, rendered a concurring period of 7000327660000000000♠3.2766±0.0003 hours with an amplitude of 0.33 in magnitude.
According to the surveys carried out by the Japanese Akari satellite and the NEOWISE mission of the U.S Wide-field Infrared Survey Explorer, the asteroid's surface has an albedo of 0.14 and 0.13, respectively, while the Collaborative Asteroid Lightcurve Link (CALL) assumes an albedo of 0.10, which is untypically low for stony bodies. Both, the space-based surveys and CALL agree closely on a diameter estimate in the range of 12.69 to 13.29 kilometers.
ABT (TV station)
ABT is the Australian Broadcasting Corporation's television station in Hobart, Tasmania. It began broadcasting on 4 June 1960, with studios in inner city Hobart and transmitter at Mount Wellington.
The analogue signal for ABT was shut off at 9.00am AEST, Tuesday, 9 April 2013.
Programming
Local programming
ABC News Tasmania is presented by Peter Gee on weeknights with weather presenter Simon McCulloch. Weekend bulletins are presented by Angela Ross. The weeknight bulletins also incorporate national finance segment presented by Alan Kohler in Melbourne.
7.30 Tasmania, a locally produced current affairs program, airs every Friday night at 7:30 pm and is presented by Airlie Ward.
Network programming
Relay stations
The following stations relay ABT throughout Tasmania:
Notes:
Podcasts:
