ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
PDB rendering based on 1e79.
Available structures PDB Human UniProt search: PDBe, RCSB List of PDB id codes 1e79, 1h8e, 2ck3, 2jdi
Identifiers
Symbols	ATP5E; ATPE; MC5DN3
External IDs	OMIM: 606153 GeneCards: ATP5E Gene
EC number	3.6.3.14
Gene Ontology Molecular function • hydrolase activity • ATPase activity • transmembrane transporter activity • hydrogen ion transporting ATP synthase activity, rotational mechanism • proton-transporting ATPase activity, rotational mechanism Cellular component • mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) • mitochondrion • mitochondrial proton-transporting ATP synthase complex • mitochondrial matrix • membrane Biological process • ATP catabolic process • ion transport • proton transport • respiratory electron transport chain • mitochondrial ATP synthesis coupled proton transport • mitochondrial ATP synthesis coupled proton transport • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	514	n/a
Ensembl	ENSG00000124172	n/a
UniProt	P56381	n/a
RefSeq (mRNA)	NM_001001977.1	n/a
RefSeq (protein)	NP_001001977.1	n/a
Location (UCSC)	Chr 20: 57.6 – 57.61 Mb	n/a
PubMed search	[1]	n/a
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Mitochondrial ATP synthase epsilon chain

ground state structure of f1-atpase from bovine heart mitochondria (bovine f1-atpase crystallised in the absence of azide)
Identifiers
Symbol	ATP-synt_Eps
Pfam	PF04627
InterPro	IPR006721
SCOP	1e79
SUPERFAMILY	1e79
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

ATP synthase subunit epsilon, mitochondrial is an enzyme that in humans is encoded by the ATP5E gene.^[1][2]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the epsilon subunit of the catalytic core. Two pseudogenes of this gene are located on chromosomes 4 and 13.^[2]

The epsilon subunit is located in the stalk region of the F1 complex, and acts as an inhibitor of the ATPase catalytic core. The epsilon subunit can assume two conformations, contracted and extended, where the latter inhibits ATP hydrolysis. The conformation of the epsilon subunit is determined by the direction of rotation of the gamma subunit, and possibly by the presence of ADP. The extended epsilon subunit is thought to become extended in the presence of ADP, thereby acting as a safety lock to prevent wasteful ATP hydrolysis.^[3]

References [link]

Further reading [link]

v t e PDB gallery 1e79: BOVINE F1-ATPASE INHIBITED BY DCCD (DICYCLOHEXYLCARBODIIMIDE)   1h8e: (ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)   2ck3: AZIDE INHIBITED BOVINE F1-ATPASE   2jdi: GROUND STATE STRUCTURE OF F1-ATPASE FROM BOVINE HEART MITOCHONDRIA (BOVINE F1-ATPASE CRYSTALLISED IN THE ABSENCE OF AZIDE)

This article incorporates text from the public domain Pfam and InterPro IPR006721

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