ATF6
Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein response.
Function
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.
See also
Interactions
ATF6 has been shown to interact with YY1 and Serum response factor.
References
Further reading
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Podcasts:
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by Stranglers
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by Gym Class Heroes
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by Charlie
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by Nonce
Joy De Viva
by: StranglersShe wiped the smile right off my face
And hid it away in a secret place
The night was dark and the ground was cold
I slipped myself into a pool
I saw the trees but not the wood
And floated in an icey flood
As cold began to freeze my heart
I heared a voice come through the dark
Bring up the coals
Light up the fire
Joy de viva
Joy de viva
Smile your shining smile on me
If you see her
Say I need her
Joy de viva
Joy de viva
Now sunburned men tell tales of me
Of how I sail the ocean deep
Upon the brow I shade my face
Searching for that sate of grace
Every night the moon appears
She shows me that I need not fear
The crashing rocks and siren wind
And I will find her in the end
Then I will run