ATF1
Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.
Clinical significance
Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
Podcasts:
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by Stranglers
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by Gym Class Heroes
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by Charlie
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by Nonce
Joy De Viva
by: StranglersShe wiped the smile right off my face
And hid it away in a secret place
The night was dark and the ground was cold
I slipped myself into a pool
I saw the trees but not the wood
And floated in an icey flood
As cold began to freeze my heart
I heared a voice come through the dark
Bring up the coals
Light up the fire
Joy de viva
Joy de viva
Smile your shining smile on me
If you see her
Say I need her
Joy de viva
Joy de viva
Now sunburned men tell tales of me
Of how I sail the ocean deep
Upon the brow I shade my face
Searching for that sate of grace
Every night the moon appears
She shows me that I need not fear
The crashing rocks and siren wind
And I will find her in the end
Then I will run