ARID2
AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene.
Function
ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors.
Structure
The ARID2 protein contains two conserved C-terminal C2H2 zinc fingers motifs, a region rich in the amino acid residues proline and glutamine, a RFX (regulatory factor X)-type winged-helix DNA-binding domain, and a conserved N-terminal AT-rich DNA interaction domain—the last domain for which the protein is named.
Clinical significance
Mutation studies have revealed ARID2 to be a significant tumor suppressor in many cancer subtypes. ARID2 mutations are prevalent in hepatocellular carcinoma and melanoma. Mutations are present in a smaller but significant fraction in a wide range of other tumors.ARID2 mutations are enriched in hepatitis C virus-associated hepatocellular carcinoma in the US and European patient populations compared with the overall mutation frequency.
Podcasts:
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by Airdate
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by Airdate
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by Airdate
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by Airdate
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by Airdate
Everytime
by: AirdateYou, were always the kind of girl to call me at 3am,
We were only best of friends.
I, kept this secret kept a lie, deep down locked inside,
But I've got nothing left to hide.
I've got feelings that I can't deny.
Everytime you fall,
I will pick you up baby.
Everytime you fall,
I won't let your heart hit the ground.
I'll always be around.
I'll never ever let you down.
Me, Just put a little faith in me.
I am trying hard to make you see,
That we were always meant to be.
I, I am not just your typical guy.
I'll never let a day go by,
Without you here by my side.
I've got feelings that I can't deny.
Everytime you fall,
I will pick you up baby.
Everytime you fall,
I won't let your heart hit the ground.
I will always be around.
Everytime you fall,
I will pick you up baby.
(down, down, down, baby)
I'll never ever let you down.
Everytime you fall,
I will pick you up baby.
Everytime you fall,
I won't let your heart hit the ground.
I will always be around.
I'll never ever let you down.