ARHGEF12

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.

Clinical significance

This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.

Interactions

ARHGEF12 has been shown to interact with:

References

Further reading