Aprataxin

Aprataxin is a protein that in humans is encoded by the APTX gene.

This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.

Function

Aprataxin removes AMP from DNA ends following abortive ligation attempts by DNA Ligase IV during non-homologous end joining, thereby permitting subsequent attempts at ligation.

Interactions

Aprataxin has been shown to interact with:

References

Further reading

External links

List of fictional toxins

This is a list of toxins, poisons, chemical weapons and biological weapons from works of fiction (usually in fantasy and science fiction). The toxins are divided into three alphabetical groups: fictional poisons, fictional chemical and biological weapons, and fictional mutagens.

Fictional poisons

This is the list for fictional poisons, the toxins that are used to hurt or kill on an individual scale.

Fictional chemical/biological weapons

This is the list of fictional chemical weapons. Fictional chemical weapons are toxins that are used on large scale, by either military, paramilitary or terrorist organizations.

Fictional mutagens

While real-world mutagens produce genetic alterations, or mutations, fictional substances often produce sudden, visible changes in the morphology of organisms. The list below therefore includes fictional substances that produce such effects, as well as more plausible mutagens.

See also

List of Case Closed characters

The manga series Case Closed, known as Meitantei Conan (名探偵コナン^?, lit. Great Detective Conan, officially translated as Detective Conan) in Japan, features a large list of recurring fictional characters originally created by Gosho Aoyama. The series takes place in modern-day Japan and follows amateur detective Jimmy Kudo who solves cases in an episodic fashion while in his childhood body and under the alias Conan Edogawa. He is joined by childhood friend Rachel Moore, and her father Richard Moore who runs a Detective agency. Throughout the series, Conan interacts and befriends many characters from various groups: the Tokyo Metropolitan Police, the local police in Conan's prefecture; The Junior Detective League, a group of children who solves mysteries for their clients; The FBI. He also befriends a few individuals who know of his true identity: Dr. Agasa, who provides Jimmy with various spy gadgets; Harley Hartwell, a high school detective from Osaka; and Anita Hailey, who has also transformed into a child.