Apolipoprotein C3
Apolipoprotein C-III also known as apo-CIII is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL).
Structure
ApoCIII is a relatively small protein containing 79 amino acids that can be glycosylated at threonine-74. The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal- GalNAc), further modified with up to 2 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties.
Function
APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to inhibit hepatic uptake of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. Recent evidences suggest an intracellular role for Apo-CIII in promoting the assembly and secretion of triglyceride-rich VLDL particles from hepatic cells under lipid-rich conditions. However, two naturally occurring point mutations in human apoC3 coding sequence, namely Ala23Thr and Lys58Glu have been shown to abolish the intracellular assembly and secretion of triglyceride-rich VLDL particles from hepatic cells.
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
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by Epik High
Kill This Love
by: Epik HighENGLISH:
Somebody help me kill this!
Love. Kill this love. Kill this love. Love.
Somebody help me kill this!
Love. Kill this love. Kill this love. Love. Please don't die.
I should cut off the breath of my memories of you.
I've set fire to our recollections.
I hoped that my regrets will become a pile of ash
But they've only gotten hotter.
Even when I fill the bathtub with water
And dip myself in it to extinguish the fire
I hold my breath and soon, you come up again.
I hold on to the regrets that have come up.
I cover the eyes of memories that are watching me.
I roll up my hatred and look around.
It's a desert everywhere, where I want to find tears.
I should bury away my little affections.
My emotions are still soft.
The line that's been shaken because of its weakness.
I should draw it well and finish if off.
Save me.
Please save me.
Save me.
Somebody help me kill this!
Love. Kill this love. Kill this love. Love. Please don't die.
Somebody help me kill this!
Love, love. Love, love.
Kill, kill, kill, kill this love.
Love, love. Love, love.
Kill, kill, kill, kill this.
I can't kill, kill, kill this love.
No, no, no, no.
God help me kill, kill, kill, kill, kill, this love.
Kill this love.
Every rainy night, you come looking for me again.
The pieces of memories, buried deep in my heart, fly towards me like an arrow.
You used to be my dream, so why?
You become a nightmare every night again.
You push me off into despair, when I don't even have wings.
Please answer me that it's over now.
It didn't work. Since you left me, my heart had a hole. Gunshot.
Using ‘disinfection' as my excuse,
I only depend on alcohol and drink it up in one shot like poison spreading in my whole body.
These days, I black out every day.
My hungry lonelienss starves me.
My thirsty regrets suffocate me.
If you live, I'll die. Don't you know?
Save me.
Please save me.
Save me.
Somebody help me kill this!
Love. Kill this love. Kill this love. Love. Please don't die.
Somebody help me kill this!
Love, love. Love, love.
Kill, kill, kill, kill this love.
Love, love. Love, love.
Kill, kill, kill, kill this.
I can't kill, kill, kill this love.
No, no, no, no.
God help me kill, kill, kill, kill, kill, this love.
Kill this love.
If you open my eyes, my eyes will close.
Redrum, redrum, redrum.
If you breathe, my breath will stop.
Redrum, redrum, redrum.
Somebody help me kill this!
Somebody help me kill, kill, kill this love.
God help me kill, kill, kill, kill, kill, this love.
Goodbye dear love.
RIP.
RIP.
RIP.
Goodbye, goodbye, goodbye.
Good night.
ROMANIZED
Somebody help me kill this!
Love. Kill this love. Kill this love. Love.
Somebody help me kill this!
Love. Kill this love. Kill this love. Love.?.
Ne gieogui sum kkeunheoyaji.
Chueoge bul butyeobwatji.
Huhoega jaega doegil baraetjiman
Deo tteugeowojyeogatji.
Yokjoe mureul bada
Bul kkeugi wihae
Nunmulbada soge damado
Sumeul chama got dasi tteooreuneun neoya.
Tteooreun miryeoneul butjaba.
Nal boneun gieogui nun maga.
Nae jeungoreul geotgo dulleobwa.
Ontong nunmulman chatgopeun samak.
Janjeongeul mudeoyaji. Gamjeongi mulleo. Ajik.
Nayakhae heundeullin seon. Ijen jal geutgo kkeutnaeyaji.
Nal jom sallyeojwoyo.
Jebal jom sallyeojwoyo.
Nal jom sallyeojwoyo.
Love. Kill this love. Kill this love. Love.?.
Somebody help me kill this!
Love, love. Love, love.
Kill, kill, kill, kill this love.
Love, love. Love, love.
Kill, kill, kill, kill this.
I can't kill, kill, kill this love.
No, no, no, no.
God help me kill, kill, kill, kill, kill, this love.
Kill this love.
Bioneun bam mada neon. Nal chajaseo tto wa.
Gaseume mudeotdeon gieogui tomageun hwasallo narawa.
Nae kkumideon niga wae? Tto maeil angmongi dwae. Nalgaedo
Eomneun nal mireo. Jeolmangeuro.
Ijeneun kkeuchira daedaphaejwo.
Soyongeopdeorago. Nega nal tteonago nae maeumeun gumeongna. Gunshot.
Sodogeul pinggyero sureman gidaego onmome dokcheoreom one shot.
Yojeumeun maennal pilleumi kkeunkyeo.
Heogijin oeroumi nal gurmgyeo.
Mongmareun miryeoni mogeul jolla.
Nega salmyeon naega jugeo. Molla?
Nal jom sallyeojwoyo.
Jebal jom sallyeojwoyo.
Nal jom sallyeojwoyo.
Somebody help me kill this!
Love. Kill this love. Kill this love. Love.?.
Somebody help me kill this!
Love, love. Love, love.
Kill, kill, kill, kill this love.
Love, love. Love, love.
Kill, kill, kill, kill this.
I can't kill, kill, kill this love.
No, no, no, no.
God help me kill, kill, kill, kill, kill, this love.
Kill this love.
Nega nuneul tteumyeon nae nuni gamgyeo.
Redrum, redrum, redrum.
Nega sumeul swimyeon nae sumi makhyeo.
Redrum, redrum, redrum.
Somebody help me kill this!
Somebody help me kill, kill, kill this love.
God help me kill, kill, kill, kill, kill, this love.
Goodbye dear love.
Rip.
Rip.
Rip.
Goodbye, goodbye, goodbye.
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