Not to be confused with Aniline.
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| Anillin, actin binding protein | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ANLN; Scraps; scra | ||||||||||||
| External IDs | MGI: 1920174 HomoloGene: 41281 GeneCards: ANLN Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54443 | 68743 | |||||||||||
| Ensembl | ENSG00000011426 | ENSMUSG00000036777 | |||||||||||
| UniProt | Q9NQW6 | Q8K298 | |||||||||||
| RefSeq (mRNA) | NM_018685.2 | NM_028390.3 | |||||||||||
| RefSeq (protein) | NP_061155.2 | NP_082666.2 | |||||||||||
| Location (UCSC) | Chr 7: 36.43 – 36.49 Mb |
Chr 9: 22.14 – 22.19 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Actin-binding protein anillin is a protein that in humans is encoded by the ANLN gene.[1][2] It is a 124 kDa scaffolding protein involved in cytokinesis. It is found in high concentrations near the cleavage furrow and coincides with RhoA, the key regulator of contractile-ring formation.[3]
Structure [link]
At the N-terminus, there is an actin and myosin binding domain; at the C terminus, there is a PH domain, which is conserved and is essential for its function.[3]
References [link]
- ^ Oegema K, Savoian MS, Mitchison TJ, Field CM (Sep 2000). "Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis". J Cell Biol 150 (3): 539–52. DOI:10.1083/jcb.150.3.539. PMC 2175195. PMID 10931866. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175195.
- ^ "Entrez Gene: ANLN anillin, actin binding protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54443.
- ^ a b Piekny, AJ; Glotzer, M (2008). "Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis". Current biology : CB 18 (1): 30–6. DOI:10.1016/j.cub.2007.11.068. PMID 18158243.
Further reading [link]
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kinoshita M, Field CM, Coughlin ML, et al. (2003). "Self- and actin-templated assembly of Mammalian septins.". Dev. Cell 3 (6): 791–802. DOI:10.1016/S1534-5807(02)00366-0. PMID 12479805.
- Straight AF, Cheung A, Limouze J, et al. (2003). "Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor.". Science 299 (5613): 1743–7. DOI:10.1126/science.1081412. PMID 12637748.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. DOI:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Straight AF, Field CM, Mitchison TJ (2005). "Anillin binds nonmuscle myosin II and regulates the contractile ring.". Mol. Biol. Cell 16 (1): 193–201. DOI:10.1091/mbc.E04-08-0758. PMC 539163. PMID 15496454. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=539163.
- Mollinari C, Kleman JP, Saoudi Y, et al. (2005). "Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not.". Mol. Biol. Cell 16 (3): 1043–55. DOI:10.1091/mbc.E04-04-0346. PMC 551472. PMID 15616196. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=551472.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. DOI:10.1038/nature03207. PMID 15635413.
- Monzo P, Gauthier NC, Keslair F, et al. (2005). "Clues to CD2-associated protein involvement in cytokinesis.". Mol. Biol. Cell 16 (6): 2891–902. DOI:10.1091/mbc.E04-09-0773. PMC 1142433. PMID 15800069. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1142433.
- Zhao WM, Fang G (2005). "Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis.". J. Biol. Chem. 280 (39): 33516–24. DOI:10.1074/jbc.M504657200. PMID 16040610.
- Zhao WM, Fang G (2005). "MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13158–63. DOI:10.1073/pnas.0504145102. PMC 1201590. PMID 16129829. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1201590.
- Hall PA, Todd CB, Hyland PL, et al. (2006). "The septin-binding protein anillin is overexpressed in diverse human tumors.". Clin. Cancer Res. 11 (19 Pt 1): 6780–6. DOI:10.1158/1078-0432.CCR-05-0997. PMID 16203764.
- Suzuki C, Daigo Y, Ishikawa N, et al. (2006). "ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway.". Cancer Res. 65 (24): 11314–25. DOI:10.1158/0008-5472.CAN-05-1507. PMID 16357138.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. DOI:10.1038/nbt1240. PMID 16964243.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. DOI:10.1016/j.cell.2006.09.026. PMID 17081983.
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