AMN082
AMN082 (N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride) is a selective metabotropic glutamate receptor 7 (mGluR7) allosteric agonist. It mimics the effect of glutamate. AMN082 is the first selective mGluR7 agonist and has expanded the potential array of research opportunities on the effects of mGluR7 in the CNS.
Significance
The two main types of glutamate receptors are ionotropic receptors and metabotropic receptors. Ionotropic receptors (iGluRs) are fast-acting ligand-gated ion channels and include AMPA, Kainate and NMDA. Metabotropic receptors are G-protein coupled receptors that mediate slower, longer lasting effects through second messenger systems and are responsible for other neuronal functions that are not typically controlled by iGluRs. mGluRs are split into 3 separate groups (Group I, Group II, Group III) based on pharmacological profile, sequence homology, and preferred signal transduction pathway. mGlur7 is a member of Group III, the least studied of the groups. The discovery of AMN082 will serve as a useful pharmacological tool to expand research on Group III mGluRs.
Podcasts:
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by Ben Harper
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by Maxi Priest
Woman In You
by: Ben HarperCould've sworn I heard you say Amen this morning
Showing some kind of sign that you believe
Did it fall from your tongue without warning
Or just another,
Just another trick to fall from your sleeve
Did I hear you say that you believe in angels
I guess I bring the devil out in you
But we can both remove our halos
'cause even an angel needs love too
Even angels needs love too
The woman in you is the worry, the worry in me
The woman in you is the worry, the worry in me
Some things never.., change
Some things never stay the same
But you're so
You're so innocent
I'll take all the blame
How I hate to remember
For that means the day..., is past
Sometimes I wonder if I know her
Or if I really need to ask
Or if I really need to ask
The woman in you is the worry, the worry in me
The woman in you is the worry, the worry in me
The woman in you is the worry, the worry in me
Woman
Woman
Woman
Woman
Woman
Woman
Woman...
Oh half-man
Oh half-man
Half-man walks with no shadow
Of life the other his distaste
No apology is expected
Love carved sorry in his face
Love carved sorry in his face
The woman in you is the worry, the worry in me
The woman in you is the worry, the worry in me
The woman in you, in you, is the worry in me
In me
In me
In me
Woman
Woman
Woman
Woman
Woman
Woman
Woman
Woman
Woman
Woman...