Plerixafor
Plerixafor (INN and USAN, trade name Mozobil) is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are then extracted from the blood and transplanted back to the patient. The drug was developed by AnorMED which was subsequently bought by Genzyme.
Medical uses
Peripheral blood stem cell mobilization, which is important as a source of hematopoietic stem cells for transplantation, is generally performed using granulocyte colony-stimulating factor (G-CSF), but is ineffective in around 15 to 20% of patients. Combination of G-CSF with plerixafor increases the percentage of persons that respond to the therapy and produce enough stem cells for transplantation. The drug is approved for patients with lymphoma and multiple myeloma.
Contraindications
Pregnancy and lactation
Studies in pregnant animals have shown teratogenic effects. Plerixafor is therefore contraindicated in pregnant women except in critical cases. Fertile women are required to use contraception. It is not known whether the drug is secreted into the breast milk. Breast feeding should be discontinued during therapy.
Podcasts:
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by ToTo
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by MC Eiht
We Made It
by: ToToBad timing for love: you caught me on your birthday
I could feel your heart break into a hundred pieces
We were too torn apart, now it seems so senseless
And if we're clever, we'll put it together, it may be forever
We made it, made it, made it before, I know that we can make it again
We made it, made it, made it before, I know that we can make it again
Down on my luck, you arrived just in time, my angel
Thought you'd given me up, like a rhyme that needs no reason
I want you enough to keep my life untangled
If we're clever, we'll put it together, 'cos it may be forever
I want you enough to keep my life untangled
If we're clever, we'll put it together, 'cos it may be forever
If ever we'll make it, we're gonna make it girl
And I know we can take it, we got to take it, girl
If ever we can make it, we gotta make it