Alpha-2B adrenergic receptor
The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. It is a subtype of the adrenergic receptor family. The human gene encoding this receptor has the symbol ADRA2B. ADRA2B orthologs have been identified in several mammals.
Receptor
α2-adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
Clinical significance
This gene encodes the α2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the α2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences.
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Waterboy
by: LiveWhat do you say to the child
Whose god is in the T.V.?
And what do you say to the man
Who blames the world on T.V.?
They don't even know how to sing my song
But they won't even try it
With me, with me, with me
Who is standing over playing like
The teacher
Harnessing the learned
Who try but can't leave her
I want to beg the liars to lay down
Their sirens
That play like the angels
To my deep desire
Free my son
Let him walk right through the rain
Free my son
Make him waterboy
Free my son
There he stands down on the shore
Free my son
What do you say to the man
Who treats her like a mother?
And what do you say to the man
Who treats him like a father?
"Come and see my heart. Come inside
And learn"?
Come and see my soul, it's like yours,
I say it's just like yours"?
Who is making over
Idolizing princes banishing the dreamers with
Barbed-wire fences
And telling all the children who run to
Her feet
That they have no vision
And love's all diseased