Aconitase 2, mitochondrial is a protein that in humans is encoded by the ACO2 gene.
The secondary structure of ACO2 consists of numerous alternating alpha helices and beta sheets (SCOP classification: α/β alternating). The tertiary structure reveals that the active site is buried in the middle of the enzyme, and, since there is only one subunit, there is no quaternary structure. Aconitase consists of four domains: three of the domains are tightly compact, and the fourth domain is more flexible, allowing for conformational changes. The ACO2 protein contains a 4Fe-4S iron-sulfur cluster. This iron sulfur cluster does not have the typical function of participating in oxidation-reduction reactions, but rather facilitates the elimination of the citrate hydroxyl group by holding the group in a certain conformation and orientation. It is at this 4Fe-4S site that citrate or isocitrate binds to initiate catalysis. The rest of the active site is made up of the following residues: Gln72, Asp100, His101, Asp165, Ser166, His167, His147, Glu262, Asn258, Cys358, Cys421, Cys424, Cys358, Cys421, Asn446, Arg447, Arg452, Asp568, Ser642, Ser643, Arg644, Arg580. Their functions have yet to be elucidated.
Uh, yeah y'know, shit is wild he, heh
Can't complain though I'm alive
Healthy and all a that knahmsayin?
Just tryin' to do my thang, praise to all
Bust it that nigga Slick Rick said, I waited long time sweatin' it
I got jerked but now I'm gettin' it, hazy like asthma bizarre disaster
Stress almost held me down from bein' a master
The faster preacher, poet, a teacher, it's been so long like Monifah
Believe that I'm needed, in rappin', I breathe this
Some pick up a microphone and can't even achieve this
Oscar award winning your shit, I'm bored with it
Stop copy-catting son
(Why?)
'Cause your dog did it
Get your own lingo, make up your own jingle
Ten years later you be bitin' my single
Primo, take it downtown, swing it
Intervenin' on the board, sensimil steamin', yeah
Catch the vibe like a tribal dance
In the clubs on the low with the boy stance
Money rubbin' with a shorty got bumped by a chump
Tell him, step off, I'm doin' the hump, yeah
I say it's my world and I won't stop
And if you stand in my way you bound to get dropped
Some wish that I was gone 'cause they know I'ma win
In a minute, I'll be makin' six G's times ten
I'm the computer, printin' out data take notes
Then analyze the information and press send
Freaky like porno, Ron Jeremy saw no
Obstacle or pussy to stop him from bonin' a hoe
Me and the mic double trouble
Chicks look at us like twins, all lovable and huggable
Prognosis, on the, mic I choke out
Had the same effects from coughin', blowin' smoke out
Architect, rap technician, man listen
It's no doubt you gonna pump this in your system
My skills ill and all of that above
Confidence, I'm not worried 'bout a street buzz
I'm O.C., who you? I never heard of ya
Get out my face 'fore I turn into a motherfuckin' murderer
I want the green like indo, a mansion, a car
A wife who's never been a bimbo
Too much to ask, well, to me that's simple
Wanna retire on a yacht called the S. S. Minnow
I say it's my world and I won't stop
And if you stand in my way, you bound to get dropped
I say it's my world and I won't stop
And if you stand in my way, you bound to get dropped
I say it's my world and I won't stop
And if you stand in my way, you bound to get dropped
I say it's my world and I won't stop
And if you stand in my way, you bound to get dropped
Top choice, this here nigga got poise
Ain't a man alive who could stop my noise
I snatch a star from the sky, spark up your lye
You stand astounded wonderin' how I did it
Now you're star struck, like I truck gold
Treatin' me like a nigga havin' a million records sold
Now a star child, phenomenon like the X-Files
Rappers know I'm comin' so they go in exile
Czar in this rap shit, comin' on your mattress
Microphone fiend, I make beats do back flips
Fear me like genocide, serious
How I do it through your stereo, mysterious
O.C. do demolition, nil competition
Like robot Kong on a destroy mission
A matter of life and death you try to fight for breath
I snatch your heart from a slice through your chest
Who the best from New York to Bogota?
Who got face thinkin' they scare me with a scar, shit?
What I be bringin' is a terrible sight
A performance never again performed on the mic
I say it's my world and I won't stop
And if you stand in my way, you bound to get dropped
I say it's my world and I won't stop
And if you stand in my way, you bound to get dropped
I say it's my world and I won't stop
And if you stand in my way, you bound to get dropped
I say it's my world and I won't stop
And if you stand in my way, you bound to get dropped