Abcc8

ATP-binding cassette, sub-family C (CFTR/MRP), member 8

Identifiers

ABCC8; ABC36; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; SUR1delta2; TNDM2

External IDs

OMIM: 600509 MGI: 1352629 HomoloGene: 68048 ChEMBL: 2071 GeneCards: ABCC8 Gene

Gene Ontology
Molecular function	• nucleotide binding • receptor activity • inward rectifier potassium channel activity • potassium channel activity • ATP binding • sulfonylurea receptor activity • potassium ion transmembrane transporter activity • ATPase activity • syntaxin binding • ATPase activity, coupled to transmembrane movement of substances
Cellular component	• plasma membrane • membrane • integral to membrane • synaptic vesicle membrane • sarcolemma
Biological process	• carbohydrate metabolic process • energy reserve metabolic process • potassium ion transport • potassium ion transport • synaptic transmission • response to pH • response to zinc ion • response to lipopolysaccharide • response to insulin stimulus • response to drug • positive regulation of potassium ion transport • small molecule metabolic process • negative regulation of insulin secretion • regulation of insulin secretion • transmembrane transport • transmembrane transport • potassium ion transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
17.41 – 17.5 Mb

Chr 7:
53.36 – 53.44 Mb

PubMed search

[1]

[2]

ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene.^[1]^[2] ABCC8 orthologs ^[3] have been identified in all mammals for which complete genome data are available.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.^[4]

1 See also
2 References
3 External links
4 Further reading

References [link]

^ Glaser B, Chiu KC, Anker R, Nestorowicz A, Landau H, Ben-Bassat H, Shlomai Z, Kaiser N, Thornton PS, Stanley CA, et al. (Nov 1994). "Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene". Nat Genet 7 (2): 185–8. DOI:10.1038/ng0694-185. PMID 7920639.
^ Thomas PM, Cote GJ, Wohllk N, Haddad B, Mathew PM, Rabl W, Aguilar-Bryan L, Gagel RF, Bryan J (May 1995). "Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy". Science 268 (5209): 426–9. DOI:10.1126/science.7716548. PMID 7716548.
^ "OrthoMaM phylogenetic marker: ABCC8 coding sequence". https://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000006071_ABCC8.xml.
^ "Entrez Gene: ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6833.

External links [link]

Further reading [link]

Aguilar-Bryan L, Bryan J (1999). "Molecular biology of adenosine triphosphate-sensitive potassium channels.". Endocr. Rev. 20 (2): 101–35. DOI:10.1210/er.20.2.101. PMID 10204114.
Meissner T, Beinbrech B, Mayatepek E (1999). "Congenital hyperinsulinism: molecular basis of a heterogeneous disease.". Hum. Mutat. 13 (5): 351–61. DOI:10.1002/(SICI)1098-1004(1999)13:5<351::AID-HUMU3>3.0.CO;2-R. PMID 10338089.
Gloyn AL, Siddiqui J, Ellard S (2006). "Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.". Hum. Mutat. 27 (3): 220–31. DOI:10.1002/humu.20292. PMID 16416420.
Bryan J, Muñoz A, Zhang X, et al. (2007). "ABCC8 and ABCC9: ABC transporters that regulate K+ channels.". Pflugers Arch. 453 (5): 703–18. DOI:10.1007/s00424-006-0116-z. PMID 16897043.
Inagaki N, Gonoi T, Clement JP, et al. (1996). "Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.". Science 270 (5239): 1166–70. DOI:10.1126/science.270.5239.1166. PMID 7502040.
Aguilar-Bryan L, Nichols CG, Wechsler SW, et al. (1995). "Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.". Science 268 (5209): 423–6. DOI:10.1126/science.7716547. PMID 7716547.
Thomas PM, Cote GJ, Hallman DM, Mathew PM (1995). "Homozygosity mapping, to chromosome 11p, of the gene for familial persistent hyperinsulinemic hypoglycemia of infancy.". Am. J. Hum. Genet. 56 (2): 416–21. PMC 1801118. PMID 7847376. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1801118.
Inagaki N, Gonoi T, Clement JP, et al. (1996). "A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.". Neuron 16 (5): 1011–7. DOI:10.1016/S0896-6273(00)80124-5. PMID 8630239.
Inoue H, Ferrer J, Welling CM, et al. (1996). "Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians.". Diabetes 45 (6): 825–31. DOI:10.2337/diabetes.45.6.825. PMID 8635661.
Nichols CG, Shyng SL, Nestorowicz A, et al. (1996). "Adenosine diphosphate as an intracellular regulator of insulin secretion.". Science 272 (5269): 1785–7. DOI:10.1126/science.272.5269.1785. PMID 8650576.
Thomas PM, Wohllk N, Huang E, et al. (1996). "Inactivation of the first nucleotide-binding fold of the sulfonylurea receptor, and familial persistent hyperinsulinemic hypoglycemia of infancy.". Am. J. Hum. Genet. 59 (3): 510–8. PMC 1914902. PMID 8751851. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1914902.
Nestorowicz A, Wilson BA, Schoor KP, et al. (1997). "Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews.". Hum. Mol. Genet. 5 (11): 1813–22. DOI:10.1093/hmg/5.11.1813. PMID 8923011.
Dunne MJ, Kane C, Shepherd RM, et al. (1997). "Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor.". N. Engl. J. Med. 336 (10): 703–6. DOI:10.1056/NEJM199703063361005. PMID 9041101.
Gribble FM, Tucker SJ, Ashcroft FM (1997). "The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.". EMBO J. 16 (6): 1145–52. DOI:10.1093/emboj/16.6.1145. PMC 1169713. PMID 9135131. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169713.
Ohta Y, Tanizawa Y, Inoue H, et al. (1998). "Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.". Diabetes 47 (3): 476–81. DOI:10.2337/diabetes.47.3.476. PMID 9519757.
Hansen T, Echwald SM, Hansen L, et al. (1998). "Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.". Diabetes 47 (4): 598–605. DOI:10.2337/diabetes.47.4.598. PMID 9568693.
Nestorowicz A, Glaser B, Wilson BA, et al. (1999). "Genetic heterogeneity in familial hyperinsulinism.". Hum. Mol. Genet. 7 (7): 1119–28. DOI:10.1093/hmg/7.7.1119. PMID 9618169.
Shyng SL, Ferrigni T, Shepard JB, et al. (1998). "Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.". Diabetes 47 (7): 1145–51. DOI:10.2337/diabetes.47.7.1145. PMID 9648840.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Membrane proteins, carrier proteins: membrane transport proteins ABC-transporter (TC 3A1)

A	A1 A2 A3 A4 A7 A8 A12 A13

B	B1 B2-3 (B2 B3) B4 B5 B6 B7 B9 B11

C	C1 C2 C3 C4 C5 C6 C7 C8-9 (C8, C9) C10 C11 C13

D	D1 D2 D3 D4

E	E1

F	F1 F2

G	G1 G2 G4 Sterolin (G5, G8)

see also ABC transporter disorders B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

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ENGLISH:
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I should cut off the breath of my memories of you.
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Love. Kill this love. Kill this love. Love. Please don't die.
Somebody help me kill this!
Love, love. Love, love.
Kill, kill, kill, kill this love.
Love, love. Love, love.
Kill, kill, kill, kill this.
I can't kill, kill, kill this love.
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God help me kill, kill, kill, kill, kill, this love.
Kill this love.
Every rainy night, you come looking for me again.
The pieces of memories, buried deep in my heart, fly towards me like an arrow.
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Using ‘disinfection' as my excuse,
I only depend on alcohol and drink it up in one shot like poison spreading in my whole body.
These days, I black out every day.
My hungry lonelienss starves me.
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Somebody help me kill this!
Love. Kill this love. Kill this love. Love. Please don't die.
Somebody help me kill this!
Love, love. Love, love.
Kill, kill, kill, kill this love.
Love, love. Love, love.
Kill, kill, kill, kill this.
I can't kill, kill, kill this love.
No, no, no, no.
God help me kill, kill, kill, kill, kill, this love.
Kill this love.
If you open my eyes, my eyes will close.
Redrum, redrum, redrum.
If you breathe, my breath will stop.
Redrum, redrum, redrum.
Somebody help me kill this!
Somebody help me kill, kill, kill this love.
God help me kill, kill, kill, kill, kill, this love.
Goodbye dear love.
RIP.
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Goodbye, goodbye, goodbye.
Good night.
ROMANIZED
Somebody help me kill this!
Love. Kill this love. Kill this love. Love.
Somebody help me kill this!
Love. Kill this love. Kill this love. Love.?.
Ne gieogui sum kkeunheoyaji.
Chueoge bul butyeobwatji.
Huhoega jaega doegil baraetjiman
Deo tteugeowojyeogatji.
Yokjoe mureul bada
Bul kkeugi wihae
Nunmulbada soge damado
Sumeul chama got dasi tteooreuneun neoya.
Tteooreun miryeoneul butjaba.
Nal boneun gieogui nun maga.
Nae jeungoreul geotgo dulleobwa.
Ontong nunmulman chatgopeun samak.
Janjeongeul mudeoyaji. Gamjeongi mulleo. Ajik.
Nayakhae heundeullin seon. Ijen jal geutgo kkeutnaeyaji.
Nal jom sallyeojwoyo.
Jebal jom sallyeojwoyo.
Nal jom sallyeojwoyo.
Love. Kill this love. Kill this love. Love.?.
Somebody help me kill this!
Love, love. Love, love.
Kill, kill, kill, kill this love.
Love, love. Love, love.
Kill, kill, kill, kill this.
I can't kill, kill, kill this love.
No, no, no, no.
God help me kill, kill, kill, kill, kill, this love.
Kill this love.
Bioneun bam mada neon. Nal chajaseo tto wa.
Gaseume mudeotdeon gieogui tomageun hwasallo narawa.
Nae kkumideon niga wae? Tto maeil angmongi dwae. Nalgaedo
Eomneun nal mireo. Jeolmangeuro.
Ijeneun kkeuchira daedaphaejwo.
Soyongeopdeorago. Nega nal tteonago nae maeumeun gumeongna. Gunshot.
Sodogeul pinggyero sureman gidaego onmome dokcheoreom one shot.
Yojeumeun maennal pilleumi kkeunkyeo.
Heogijin oeroumi nal gurmgyeo.
Mongmareun miryeoni mogeul jolla.
Nega salmyeon naega jugeo. Molla?
Nal jom sallyeojwoyo.
Jebal jom sallyeojwoyo.
Nal jom sallyeojwoyo.
Somebody help me kill this!
Love. Kill this love. Kill this love. Love.?.
Somebody help me kill this!
Love, love. Love, love.
Kill, kill, kill, kill this love.
Love, love. Love, love.
Kill, kill, kill, kill this.
I can't kill, kill, kill this love.
No, no, no, no.
God help me kill, kill, kill, kill, kill, this love.
Kill this love.
Nega nuneul tteumyeon nae nuni gamgyeo.
Redrum, redrum, redrum.
Nega sumeul swimyeon nae sumi makhyeo.
Redrum, redrum, redrum.
Somebody help me kill this!
Somebody help me kill, kill, kill this love.
God help me kill, kill, kill, kill, kill, this love.
Goodbye dear love.
Rip.
Rip.
Rip.
Goodbye, goodbye, goodbye.

Contents

See also [link]