ATP-binding cassette, sub-family A (ABC1), member 4, also known as ABCA4 or ABCR, is a protein which in humans is encoded by the ABCA4 gene.
ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. The gene was first cloned and characterized in 1997 as a gene that causes Stargardt disease, an autosomal recessive disease that causes macular degeneration. The ABCA4 gene transcribes a large retina-specific protein with two transmembrane domains (TMD), two glycosylated extracellular domains (ECD), and two nucleotide-binding domains (NBD). The ABCA4 protein is almost exclusively expressed in retina localizing in outer segment disk edges of rod photoreceptors.
ATP-binding cassette sub-family A member 13 also known as ABCA13 is a protein that in humans is encoded by the ABCA13 gene on chromosome 7. It belongs to the wide ATP-binding cassette family of proteins. The protein contains 5058 residues, and is currently the largest known protein of the ABC family.
One study suggests that rare variations and mutations of the gene may be linked to psychiatric disorders such as schizophrenia, bipolar disorder, and depression.
ATP-binding cassette sub-family A member 2 is a protein that in humans is encoded by the ABCA2 gene.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene.
LA MAS BELLA HISTORIA
QUE SE PUEDE CONTAR
LLEVA ESCRITO EL DOLOR
QUE PROVOCA UN AMOR
QUE NADIE ENTENDERÁ
SIEMPRE TODO A ESCONDIDAS
SIEMPRE MIRANDO ATRÁS
SÓLO LA OSCURIDAD
PUEDE SER NUESTRO HOGAR
DONDE CRECERÁ ESTE AMOR
Y NO... NO QUIERO MAS CLASES DE FALSA MORAL
QUE NADIE ES CULPABLE POR AMAR
EN MI PECHO NO LATE LA RAZÓN
SÓLO EL MAS SINCERO Y PURO AMOR
NO HAY MAR EN EL MUNDO
NI FUERZA CAPAZ
QUE PUEDA ESTE FUEGO APAGAR
SÓLO EL TIEMPO PUEDE SER NUESTRO JUEZ
TE QUISE, QUIERO Y QUERRÉ
QUE DIFÍCIL LO NUESTRO
QUE BONITO A LA VEZ
ES TAN DURO TENER
QUE BUSCAR LOS PORQUES
A ESTA SITUACIÓN
NUESTRO AMOR ES LA ISLA
EL TESORO ERES TÚ... OH DIOS
CON MI VIDA DARÉ
SÓLO EL BRAZO A TORCER
BIEN LO SABES, MI AMOR
NO... NO QUIERO MAS CLASES DE FALSA MORAL
QUE NADIE ES CULPABLE POR AMAR
EN MI PECHO NO LATE LA RAZÓN
SÓLO EL MAS SINCERO Y PURO AMOR
NO HAY MAR EN EL MUNDO
NI FUERZA CAPAZ
QUE PUEDA ESTE FUEGO APAGAR
SÓLO EL TIEMPO PUEDE SER NUESTRO JUEZ
TE QUISE, QUIERO Y QUERRÉ
NO... NO QUIERO MAS CLASES DE FALSA MORAL
QUE NADIE ES CULPABLE POR AMAR
EN MI PECHO NO LATE LA RAZÓN
SÓLO EL MAS SINCERO Y PURO AMOR
NO HAY MAR EN EL MUNDO
NI FUERZA CAPAZ
QUE PUEDA ESTE FUEGO APAGAR
SÓLO EL TIEMPO PUEDE SER NUESTRO JUEZ
TE QUISE, QUIERO Y QUERRÉ