The road begins as Frodsham Street in the centre of Chester at its junction with Eastgate Street A51 and heads north-eastwards out of the city. Just outside the city, the A56 crosses Junction 12 of the M53 motorway, continuing in a north easterly direction. The road passes through the towns and villages of Mickle Trafford, Helsby and Frodsham whilst roughly paralleling the course of the south side of the M56 motorway. After leaving Frodsham, the A56 crosses the M56 at Junction 11 and passes the towns of Runcorn and Warrington, taking up a more easterly direction to again parallel the course of the north side of the motorway.