A-349,821
A-349,821 is a potent and selective histamine H3 receptor antagonist (or possibly an inverse agonist). It has nootropic effects in animal studies, although there do not appear to be any plans for clinical development at present and it is currently only used in laboratory research.
See also
H3 receptor antagonist
References
↑ Faghih, R; Dwight, W; Pan, JB; Fox, GB; Krueger, KM; Esbenshade, TA; McVey, JM; Marsh, K; Bennani, YL; Hancock, AA (2003). "Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 13 (7): 1325–8. doi:10.1016/S0960-894X(03)00118-5. PMID 12657274.
↑ Witte, DG; Yao, BB; Miller, TR; Carr, TL; Cassar, S; Sharma, R; Faghih, R; Surber, BW; Esbenshade, TA; Hancock, AA; Krueger, KM (2006). "Detection of multiple H3 receptor affinity states utilizing 3HA-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand". British Journal of Pharmacology 148 (5): 657–70. doi:10.1038/sj.bjp.0706752. PMC 1751875. PMID 16715122.
