78 Derngate

78 Derngate is a Grade II* listed Georgian house in the Cultural Quarter of Northampton, England, originally built in 1815. It is noted for its interior, which was extensively remodelled in 1916 and 1917 by noted architect Charles Rennie Mackintosh for businessman Wenman Joseph Bassett-Lowke as his first marital home.

The rear elevation also features a striking extension with two elevated balconies which, in 1916, overlooked meadowland to the edge of Northampton. The design origins of this extension have been the subject of some scholarly debate and a myth of Mackintosh as a modernist pioneer in his late career has persisted. However, recent research suggests that Bassett-Lowke and Alexander Ellis Anderson (a Northampton-based architect who supervised the remodelling) may also have had a hand in the design of this structure as well as Mackintosh.

In 1926 the Bassett Lowkes moved to New Ways, a pioneering modernist house designed by Peter Behrens close to Abington Park.

Between 1964 and 1993 the building was used by Northampton High School for girls, initially as offices but later as classrooms. In 2002 work started to restore the house to Mackintosh's original design. This work was under the direction of architects John McAslan + Partners and involved a team of specialist contractors for expert restoration, or replication of, the original features of the Mackintosh period scheme.