5O or 5-O or Five-O can refer to:

• the IATA code for Europe Airpost
• 5-O-caffeoylquinic acid; see Chlorogenic acid
• 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase
• 5-O-Methyl (disambiguation)
• Cyanidin 3-O-rutinoside 5-O-glucosyltransferase
• Anthocyanin 5-O-glucoside 6'''-O-malonyltransferase
• a slang term for a Ford Mustang GT automobile with a 32-valve 5.0 L engine

Stylized as "Five-O"

• Five-O, an American slang term for law enforcement
• Hawaii Five-O, an American television police drama airing from 1968 to 1980
  • Hawaii Five-O (album), a 1969 album by The Ventures
  • Hawaii Five-0, a re-imagining of the 1968 series premiering in 2010
• Five-O (album), a 1985 Hank Williams, Jr. album
• Five-O (song), a 2007 single by Elephant Man from the album Let's Get Physical
• Ninja Five-O, A game for the Nintendo_Game_Boy_Advance, released in 2003

See also [link]

• O5 (disambiguation)

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