50s

This is a list of events occurring in the 50s, ordered by year.

50

By place

Roman Empire

1950s

The 1950s (pronounced "nineteen-fifties", commonly abbreviated as the "Fifties") was a decade of the Gregorian calendar that began on January 1, 1950 and ended on December 31, 1959.

By its end, the world had largely recovered from World War II and the Cold War developed from its modest beginning in the late-1940s to a hot competition between the United States and the Soviet Union by the early-1960s.

Clashes between communism and capitalism dominated the decade, especially in the Northern Hemisphere. The conflicts included the Korean War in the beginnings of the decade and the beginning of the Space Race with the launch of Sputnik 1. Along with increased testing of nuclear weapons (such as RDS-37 and Upshot-Knothole), this created a politically conservative climate. In the United States, the Second Red Scare caused Congressional hearings by both houses in Congress and anti-communism was the prevailing sentiment in the United States throughout the decade. The beginning of decolonization in Africa and Asia occurred in this decade and accelerated in the following decade.

50S

50S is the larger subunit of the 70S ribosome of prokaryotes. It is the site of inhibition for antibiotics such as macrolides, chloramphenicol, clindamycin, and the pleuromutilins. It includes the 5S ribosomal RNA and 23S ribosomal RNA.

Structure

50S, roughly equivalent to the 60S ribosomal subunit in eukaryotic cells, is the larger subunit of the 70S ribosome of prokaryotes. The 50S subunit is primarily composed of proteins but also contains single-stranded RNA known as ribosomal RNA (rRNA). rRNA forms secondary and tertiary structures to maintain the structure and carry out the catalytic functions of the ribosome.

X-ray crystallography has yielded electron density maps allowing the structure of the 50S in Haloarcula marismortui to be determined to 2.4Å resolutionand of the 50S in Deinococcus radiodurans to 3.3Å. The large ribosomal subunit (50S) is approximately twice as massive as the small ribosomal subunit (30S). The model of Hm 50S, determined in 2000 by Nenad Ban and colleagues in the laboratory of Thomas Steitz and the laboratory of Peter Moore, includes 2711 of the 2923 nucleotides of 23S rRNA, all 122 nucleotides of its 5S rRNA, and structure of 27 of its 31 proteins.