5-APB (5-(2-aminopropyl)benzofuran, 1-benzofuran-5-ylpropan-2-amine, benzofury) is a triple monoamine reuptake inhibitor with Ki values of 180, 265 and 811 nM for NET, DAT and SERT respectively as well as being a potent agonist for the 5-HT2A and 5-HT2B receptors (Ki of 14nM at 5-HT2B). This agonism for 5-HT2B makes it likely that 5-APB would be cardiotoxic with long term use, as seen in other 5-HT2B agonists such as fenfluramine and MDMA. The subjective effects and structure-activity relationship suggest that 5-APB is also a monoamine releasing agent.
5-APB is commonly found as the succinate and hydrochloride salt. The hydrochloride salt is 10% more potent by mass and doses should be adjusted accordingly.
5-APB is also an agonist of the 5-HT2C receptor as well as a triple monoamine reuptake inhibitor. It has been sold as a designer drug since 2010.
A forensic standard of 5-APB is available, and the compound has been posted on the Forendex website of potential drugs of abuse. The US Department of Justice and DEA have also conducted studies concerning the detection of 5-APB.
Tomorrow's coming 'round
A hair-pin curve in the road
She's got a run in her stocking
And she's missing the heel of her shoe
Got up this morning rolled out of bed
I spilled a diet coke
Called my mother said, "Hi"
What I meant to say was, "Why is your life a joke?"
Then, I went down to that ugly bar and
I clicked my heels three times just like you said
And I climbed that road to your empty house
The anticipation was a turn on
But you let me down
'Coz, I stood on that empty street alone
I said, "I'm ready for my close up now, Mr. Demille"
I waited for the light, but it never shone
Well I wonder what you do with that expensive piece of land
That overlooks a billion years of history
I have a sneaking suspicion, you will never understand
Hey maybe I'll see you down by the Rocky and Bullwinkle
And we can talk to that charlatan psychic
And she can paint a prettier picture of your future
'Coz that day in my life, that day in my life
I dreamt tomorrow, had a prettier face
I dreamt tomorrow, would have better things to say
Than, "You look like shit, what's your problem, bitch?
You're legs feel like sandpaper, you can't do anything right"
'Coz that day, never should have taken place
'Coz this day, in my life still cannot explain
Why I listened in the first place to you?
Oh yeah, something else
I hope one day you call up your father
And you have the guts to tell him, how he hurt you
And he made you hurt another