Internal Revenue Service

The Internal Revenue Service (IRS) is the revenue service of the United States federal government. The government agency is a bureau of the Department of the Treasury, and is under the immediate direction of the Commissioner of Internal Revenue. The IRS is responsible for collecting taxes and the administration of the Internal Revenue Code. It has also overseen various benefit programs, and enforces portions of the Affordable Care Act.

The first income tax was assessed in 1862 to raise funds for the American Civil War, with a rate of 3%. Today the IRS collects over $2.4 trillion each tax year. It processes around 234 million tax returns annually.

History

American Civil War (1861–65)

In July 1862, during the Civil War, President Abraham Lincoln and Congress created the office of Commissioner of Internal Revenue and enacted a temporary income tax to pay war expenses (see Revenue Act of 1862). The position of Commissioner exists today as the head of the Internal Revenue Service.

IRS4

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.

Interactions

IRS4 has been shown to interact with CRK and NISCH.

References

Further reading

IRS1

Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that in humans is encoded by the IRS-1 gene. It contains a single pleckstrin homology (PH) domain at the N-terminus and a PTB domain ca. 40 residues downstream of this. Together with IRS2, IRS3 (pseudogene) and IRS4, it is homologous to the Drosophila protein chico, whose disruption extends the median lifespan of flies up to 48%. Similarly, Irs1 mutant mice experience moderate life extension and delayed age-related pathologies.

Function

Insulin receptor substrate 1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to intracellular pathways PI3K / Akt and Erk MAP kinase pathways.

Tyrosine phosphorylation of the insulin receptors or IGF-1 receptors, upon extracellular ligand binding, induces the cytoplasmic binding of IRS-1 to these receptors, through its PTB domains. Multiple tyrosine residues of IRS-1 itself are then phosphorylated by these receptors. This enables IRS-1 to activate several signalling pathways, including the PI3K pathway and the MAP kinase pathway.

The Times

The Times is a British daily national newspaper based in London. It began in 1785 under the title The Daily Universal Register and became The Times on 1 January 1788. The Times and its sister paper The Sunday Times (founded in 1821) are published by Times Newspapers, since 1981 a subsidiary of News UK, itself wholly owned by the News Corp group headed by Rupert Murdoch. The Times and The Sunday Times do not share editorial staff, were founded independently and have only had common ownership since 1967.

In 1959, historian of journalism Allan Nevins analysed the importance of The Times in shaping the views of events of London's elite:

The Times is the first newspaper to have borne that name, lending it to numerous other papers around the world, including The Times of India (founded in 1838), The Straits Times (Singapore) (1845), The New York Times (1851), The Irish Times (1859), Le Temps (France) (1861-1942), the Cape Times (South Africa) (1872), the Los Angeles Times (1881), The Seattle Times (1891), The Manila Times (1898), The Daily Times (Malawi) (1900), El Tiempo (Colombia) (1911), The Canberra Times (1926), and The Times (Malta) (1935). In these countries, the newspaper is often referred to as The London Times or The Times of London.

Multiplication sign

The multiplication sign or times sign is the symbol ×. The symbol is similar to the lowercase letter x but is a more symmetric saltire, and has different uses. It is also known as St. Andrew's Cross and dimension sign.

Uses

In mathematics, the symbol × (read as times or multiplied by) is primarily used to denote the

In biology, the multiplication sign is used in a botanical hybrid name, where it is read as "cross".

The multiplication sign is also used by historians for an event between two dates. When employed between two dates, for example 1225 and 1232, 1225×1232 means "no earlier than 1225 and no later than 1232". It can also be used in a date range: 1225×1232–1278.

History

The × symbol for multiplication was introduced by William Oughtred in 1631. It was chosen for religious reasons to represent the cross.

100 Times

100 Times is Avail's first release on Fat Wreck Chords, done so in 1999. It is a re-recording of five songs (plus a recording of one song of which a different recording would appear on their first full-length album for Fat Wreck Chords in 2000, One Wrench) that were originally released on previous Avail full-length albums by Lookout! Records.

Track listing