2-Bromo-LSD, also known as BOL-148, is a derivative of lysergic acid invented by Albert Hofmann, as part of the original research from which the closely related compound LSD was also derived. 2-bromo-LSD was found to be inactive as a psychedelic and so was comparatively little researched for many years, although its similar behavior in the body made it useful for radiolabelling studies. It was found to bind to many of the same receptor targets as LSD, but acting as a neutral antagonist rather than an agonist. However its generally similar behavior to LSD in some respects has shown to be very useful in one specific area, the treatment of cluster headaches. These debilitating attacks have been known for some time to be amenable to treatment with certain hallucinogenic drugs such as LSD and psilocybin, but because of the illegal status of these drugs and the kind of mental changes they induce, research into their medical use has been slow and therapeutic application limited to very specific circumstances under strict supervision. It had been thought that this specific therapeutic action against cluster headaches was limited to hallucinogenic drugs of this type, and would always present a major barrier to their clinical use. However a serendipitous discovery found that 2-bromo-LSD is also able to produce this therapeutic effect, despite lacking the other effects of LSD. This has led to a resurgence of interest and research into 2-bromo-LSD and its possible medical uses. Some isolated incidents of hallucinogenic responses have been reported, but as with other non-hallucinogenic LSD analogues such as lisuride, this appears to be a rare side effect occurring only in individuals with an as yet unexplained susceptibility to this reaction.
USS Oak Hill (LSD-7) was an Ashland-class dock landing ship of the United States Navy, named in honor of Oak Hill, the Virginia estate of President James Monroe (1758–1831).
Oak Hill, originally designated as a Mechanized Artillery Transport, APM-7, was laid down by the Moore Dry Dock Co., Oakland, California, 9 March 1943; launched on 25 June 1943, sponsored by Mrs. Robert E. Garrels; and commissioned on 5 January 1944, Commander Carl A. Peterson in command.
Following shakedown and amphibious training off southern California, Oak Hill, designed to serve as a cargo and transport type amphibious ship and as a floating dry dock, ferried cargo between the west coast and Hawaii. In early May she engaged in rehearsals for Operation Forager, the thrust into the Marianas, and, at the end of the month, sailed west in Task Group 52.16 (TG 52.16). With tank-bearing LCMs and troops of the 2nd Marine Division on board, she arrived in transport area off Saipan early on 15 June. Her boats soon away and headed for the beachhead, the LSD took up repair duties, working on LCMs, LCVPs and LCTs until the 22nd. She then headed back to Pearl Harbor to resume shuttling cargo and landing craft between Hawaii and the west coast.
USS Comstock (LSD-19) was a Casa Grande-class dock landing ship of the United States Navy. She was the first navy ship named in honor of the Comstock Lode in Nevada, discovered in 1859, which was one of the richest deposits of precious metals known in the world.
As of 2011, the ship is in active service at Republic of China Navy as ROCS Chung Cheng (LSD-191).
Comstock was launched on 28 April 1945 by Newport News Shipbuilding and Dry Dock Co., Newport News, Va., sponsored by Mrs. H. O. Redue, Jr.; and commissioned on 2 July 1945, Lieutenant Commander J. C. Rochester, USNR, in command.
Comstock sailed from Norfolk on 6 September 1945 and after calling at Pearl Harbor en route, arrived at Okinawa 20 October to join in the occupation activities of amphibious forces in China and Japan. She served in the Far East until 1946, then returned to the west coast, entering Puget Sound Naval Shipyard on 26 May for conversion to a boat pool ship.
After operating along the west coast, Comstock trained in the Hawaiian Islands from July 1947. Between 28 November 1947 and 31 May 1948 she furnished boat pool services to Joint Task Force 7 for Operation Sandstone, the atomic weapons tests at Eniwetok. After calling at Yokosuka, Japan, she returned to San Francisco on 17 June and alternated local operations on the west coast with six brief tours of duty in the western Pacific until the outbreak of the Korean War.
USS Belle Grove (LSD-2) was a Ashland-class dock landing ship of the United States Navy, named in honor of Belle Grove Plantation, the birthplace of President James Madison (1751–1836) in Port Conway, Virginia.
Belle Grove was laid down on 27 October 1942 by the Moore Dry Dock Company, Oakland, California; launched on 17 February 1943, sponsored by Mrs. George M. Lowry; and commissioned at Oakland on 9 August 1943, Lieutenant Commander Morris Seavey, USNR, in command.
Following her shakedown cruise in the waters off southern California, Belle Grove sailed for Pearl Harbor on 21 October 1943. Upon arrival, the dock landing ship conducted several rehearsals for the upcoming invasion of the Gilbert Islands. In early November, she loaded troops and equipment and set sail for Makin Island. Arriving in the lagoon off Makin on 20 November, she unloaded her embarked troops and LCMs without incident later that morning. In company with Transport Division 20 (TransDiv 20), the ship cleared the island group that evening, returning to Pearl Harbor on 2 December.