25I-NBOMe
25I-NBOMe (2C-I-NBOMe, Cimbi-5, also shortened to "25I") is a psychedelic drug and derivative of the substituted phenethylamine psychedelic 2C-I. It was discovered in 2003 by chemist Ralf Heim at the Free University of Berlin, who published his findings in his PhD dissertation. The compound was subsequently investigated by a team at Purdue University led by David Nichols.
The carbon-11 labelled version of 25I-NBOMe, [11C]Cimbi-5, was synthesized and validated as a radiotracer for positron emission tomography (PET) in Copenhagen. Being the first 5-HT2A receptor full agonist PET radioligand, [11C]-CIMBI-5 shows promise as a more functional marker of these receptors, particularly in their high affinity states.
Chemistry and structure
Like other 2C-X-NBOMe molecules, 25I-NBOMe is a derivative of the 2C family of phenethylamines described by Alexander Shulgin in his book PiHKAL. Specifically, 25I-NBOMe is an N-benzyl derivative of the phenethylamine molecule 2C-I, formed by adding a 2-methoxybenzyl (BnOMe) onto the nitrogen (N) of the phenethylamine backbone. This substitution significantly increases the potency of the molecule.
Podcasts:
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by Inara George
No Poem
by: Inara GeorgeYou’re no poem once you open your mouth
I never like what you say
A carnation to cover your lips
When you speak I fall away
The exceptions are few in between
I spend time just trying to forget
Away, will you fall away
Let’s pretend that we've never met
Keep yourself within yourself
For all that you say it never gets better
In yourself within yourself
If I was you I wouldn’t talk, I’d just keep dancing
If all your moves were words
And backsteps were things you’ve denied
You’ve said, that’s right, your dead
I’m dumb, but not deaf and blind
Keep yourself within yourself
For all that you say it never gets better
In yourself within yourself
If I was you I wouldn’t talk, I’d just keep dancing
Keep yourself within yourself
For all that you say it never gets better
In yourself within yourself
If I was you I wouldn’t talk, I’d just keep dancing