Bartholomew Sharp embarks on the "Pacific Adventure", a raid on Spanish settlements on the South American west coast. One crewman, Basil Ringrose, writes an account of the expedition, later published by Alexander Esquemeling.
John Williams captures James Kelley on a slave ship of the coast of West Africa, making him a crewmember.
April 15 – Landing on the Isthmus of Darien, John Coxen leads 331 buccaneers, including Bartholomew Sharp, William Dampier, Lionel Wafer, Basil Ringrose, William Dick and John Cox, divided into 5 groups consisting of Bartholomew Sharp, Richard Sawkins, Peter Harris, John Coxon and Edmund Cook. Marching towards the Spanish stronghold of Santa Maria the buccaneers first met with the Mosquito Indians who had reported it contained a large amount of gold dust. The Spaniards however had been warned of their approach and had sent the gold to Panama and by the time the buccaneers had reached Santa Maria most of the party were in favour of stealing out on the Pacific Ocean in the Mosquito's canoes. While Coxon and his party were against the proposal, he was persuaded to stay and keep command of the expedition.