PGR

PGR may stand for:

Progesterone receptor

The progesterone receptor (PR, also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3), is a protein found inside cells. It is activated by the steroid hormone progesterone.

In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight.

Function

Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration.

After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins.

Structure

In common with other steroid receptors, the progesterone receptor has a N-terminal regulatory domain, a DNA binding domain, a hinge section, and a C-terminal ligand binding domain. A special transcription activation function (TAF), called TAF-3, is present in the progesterone receptor-B, in a B-upstream segment (BUS) at the amino acid terminal. This segment is not present in the receptor-A.

Project Gotham Racing (series)

Project Gotham Racing (PGR) was a series of racing video games developed by Bizarre Creations and published by Microsoft Studios (Xbox and Xbox 360) and Sega (Dreamcast). This franchise is exclusive to the Dreamcast, Xbox and Xbox 360 consoles, and consists of Metropolis Street Racer (Dreamcast), Project Gotham Racing (Xbox), Project Gotham Racing 2 (Xbox), Project Gotham Racing 3 (Xbox 360), and Project Gotham Racing 4 (Xbox 360).

The PGR series have a system called Kudos points. These are given for performing stunts with the vehicle (such as power sliding, overtaking another driver, two wheels, etc.). The longer the stunt is maintained, the more points the player receives. Colliding with the guard rails and other surroundings will cause the Kudos points from that stunt to be lost.

PGR2, PGR3 and PGR4 support gameplay via Xbox Live, while the first installment in the series does not.

The cover of each game in the Project Gotham Racing franchise has featured a Ferrari car on it, going from the F50 (PGR) to the Enzo (PGR2), the F430 (PGR3), and the 599 GTB Fiorano (PGR4). The car manufacturer was even the main focus of a free mobile entry in the series, PGR: Ferrari Edition for the Zune HD, similar to that of Porsche in Need for Speed: Porsche Unleashed.