DNA damage (naturally occurring)

DNA damage is an alteration in the chemical structure of DNA, such as a break in a strand of DNA, a base missing from the backbone of DNA, or a chemically changed base such as 8-OHdG. Damage to DNA that occurs naturally can result from metabolic or hydrolytic processes. Metabolism releases compounds that damage DNA including reactive oxygen species, reactive nitrogen species, reactive carbonyl species, lipid peroxidation products and alkylating agents, among others, while hydrolysis cleaves chemical bonds in DNA. Naturally occurring oxidative DNA damages arise at least 10,000 times per cell per day in humans and 50,000 times or more per cell per day in rats, as documented below.

DNA damage is distinctly different from mutation, although both are types of error in DNA. DNA damage is an abnormal chemical structure in DNA, while a mutation is a change in the sequence of standard base pairs.

DNA damage and mutation have different biological consequences. While most DNA damages can undergo DNA repair, such repair is not 100% efficient. Un-repaired DNA damages accumulate in non-replicating cells, such as cells in the brains or muscles of adult mammals and can cause aging. (Also see DNA damage theory of aging.) In replicating cells, such as cells lining the colon, errors occur upon replication of past damages in the template strand of DNA or during repair of DNA damages. These errors can give rise to mutations or epigenetic alterations. Both of these types of alteration can be replicated and passed on to subsequent cell generations. These alterations can change gene function or regulation of gene expression and possibly contribute to progression to cancer.

DNA²

DNA² (Japanese: D・N・A² ～何処かで失くしたあいつのアイツ～, Hepburn: Dī En Ei Tsū: Dokoka de Nakushita Aitsu no Aitsu) is a science fiction manga series written and illustrated by Masakazu Katsura. It was serialized across Shueisha's Weekly Shōnen Jump magazine between 1993 and 1994, spanning a total of five tankōbon volumes.

DNA² was adapted into a 12-episode anime television series which ran on Nippon Television from October 7, 1994 to December 23, 1994. This was followed by a three-episode anime original video animation (OVA) in 1995. Produced by Madhouse and Studio Deen, the anime series was directed by Jun'ichi Sakata, whereas the character designer and animation director for the series was Kumiko Takahashi. DNA² has been broadcast in Japan by Animax, which has also aired the series across its respective networks worldwide, including its English-language networks in Southeast Asia and South Asia. All 15 episodes were licensed in North America by Central Park Media until their closing in 2009. The five volumes and box set are out-of-print. Discotek Media has since re-licensed the series for a DVD release in 2014.

DNA2.0

DNA2.0 provides products and services for life science and Synthetic biology research. DNA2.0 also provides free access to research tools such as Gene Designer, DNA Atlas and a gRNA designer.

The company

DNA2.0 was founded in 2003, in Menlo Park, California. The company is privately held and continues to have all research, development and production in Menlo Park, California. It began and continues as a gene synthesis and protein engineering provider to academia, government and the pharmaceutical, chemical, agricultural and biotechnology industries. Gene Synthesis rapidly replaced molecular cloning for many academic and corporate labs, as "foundries for the biotechnology age" allowing made-to-order genes for biological research. DNA2.0 was featured on the PBS show Nova ScienceNow to show how genes are created synthetically in a lab. In 2008, the company supplied some of the DNA stretches used to create a synthetic bacterial genome.Dan Rather Reports included DNA2.0 in their episode on Synthetic Biology and how it is solving "some of the most important problems facing the world." In 2009, The Scientist named the codon design algorithms (now tradmarked as GeneGPS) developed by DNA2.0 as one of the Top 10 Innovations of the year for Life Sciences. DNA2.0 developed the Electra Vector System, a universal cloning system that utilizes the type IIS restriction enzyme SapI and T4 DNA ligase in a single-tube reaction. DNA2.0 has made some molecular components, such as synthetic fluorescent proteins, available in open-access collections of DNA parts (BioBricks Foundation). DNA2.0 is a founding member of the International Gene Synthesis Consortium (IGSC) to promote biosecurity in the gene-synthesis industry. There are over 1,100 published scientific articles using DNA2.0 products and/or services, of which 43 include company employees as an author(s).

DNA (Wanessa album)

DNA is the seventh studio album by Brazilian recording artist Wanessa, released on July 28, 2011 by Sony Music Entertainment.

Production

Musically, the album was influenced by contemporary pop, and other genres, with elements like funk carioca and R&B. DNA was produced by Mr. Jam and Dennonyx. The first information about DNA appeared in 2010 in an interview with radio Transamerica, revealing that the album would be entirely in English. The recording sessions started in São Paulo, Brazil and it was finished and mastered in New York, in the Sterling Sound Studios.

Background

On November 13, 2010 Wanessa revealed in an interview for the radio Transamerica her new album was recorded in early 2011, with an electropop dance sound, and would include the four songs from her EP "Party Line", "Stuck on Repeat", "Falling For U" and "Worth It". On January 8, 2011, against the comments that it would launch an international album, Wanessa, in an interview for Rolling Stone Brazil said that, her plans were to set herself in Brazil. In the same interview, the singer said she would be entering the studio to release her album at the end of March, which would be entirely in English and focusing on pop and a remix of the single "Stuck On Repeat", produced by American DJ Dave Aude, known by his work with Lindsay Lohan, Hilary Duff and Lady Gaga.

Damage

Damage may refer to:

General concepts

Biology and medical

Law

Entertainment

Film and television

Damage (Pharoahe Monch song)

"Damage" is a song by American hip hop artist Pharoahe Monch, released as the lead single from his fourth studio album, P.T.S.D. (Post Traumatic Stress Disorder). Prior to its release date, Pharoahe Monch's independent label, W.A.R. Media, published a visual trailer to YouTube on September 22, 2012. The song was officially made available for purchase worldwide on September 27, 2012, on the iTunes Music Store by W.A.R. Media in conjunction with Duck Down Music Inc.. The Lee Stone-produced song is the final piece to Pharoahe's "bullet" trilogy in which he anthropomorphizes a slug fired with the intent to annihilate, and tackles the issue of gun violence. The song and its cover art provide a chilling reminder that bullets have no name.

Background and concept

I don't [want to] approach the song as rhyming for the sake of riddling, but that's when I heard the chorus with a whole new meaning, coming from the perspective of a bullet like, “Listen to the way I slay your crew.” As a bullet, it doesn't [care] if you're white, black, Latino, pregnant mother, Pop, politician or whatever. I figured this was the best way to finish the trilogy.

Make This Your Own

Make This Your Own is the third and final album by British alternative rock band The Cooper Temple Clause.

It reached #33 in the UK album charts, despite not having the major label backing afforded to the band's first two albums.

Track listing

External links