Protein kinase B
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
Family members
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Mouse model with complete deletion of Akt1 manifests growth retardation and increased spontaneous apoptosis in tissues such as testes and thymus. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogene in the transforming retrovirus, AKT8.
Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport. In a mouse which is null for Akt1 but normal for Akt2, glucose homeostasis is unperturbed, but the animals are smaller, consistent with a role for Akt1 in growth. In contrast, mice which do not have Akt2, but have normal Akt1, have mild growth deficiency and display a diabetic phenotype (insulin resistance), again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. Akt isoforms are overexpressed in a variety of human tumors, and, at the genomic level, are amplified in gastric adenocarcinomas (Akt1), ovarian (Akt2), pancreatic (Akt2) and breast (Akt2) cancer.
Mount Athos
Mount Athos (/ˈæθɒs/; Greek: Όρος Άθως, Οros Αthos [ˈoros ˈaθos]) is a mountain and peninsula in Northern Greece. A World Heritage Site and autonomous polity within the Hellenic Republic under the official name Autonomous Monastic State of the Holy Mountain (Greek: Αὐτόνομη Μοναστικὴ Πολιτεία Ἁγίου Ὄρους, Aftonomi Monastiki Politia Agiou Orous), Mount Athos is home to 20 stauropegial Eastern Orthodox monasteries under the direct jurisdiction of the Ecumenical Patriarch of Constantinople.
Mount Athos is commonly referred to as the "Holy Mountain" (Greek: Ἅγιον Ὄρος, Agion Oros [ˈaʝ(i)o(n) ˈoros]) and the entity as the "Athonite State" (Greek: Αθωνική Πολιτεία, Athoniki Politia). In the Classical era, while the mountain was called Athos, the peninsula was known as Acté or Akté (Ἀκτὴ).
Mount Athos has been inhabited since the ancient times and is known for its nearly 1,800-year continuous Christian presence and its long historical monastic traditions, which date back to at least 800 A.D. and the Byzantine era. Today, over 2,000 monks from Greece and many other Eastern Orthodox countries, such as Romania, Moldova, Bulgaria, Serbia and Russia, live an ascetic life in Athos, isolated from the rest of the world. The Athonite monasteries feature a rich collection of well-preserved artifacts, rare books, ancient documents, and artworks of immense historical value.
AKT2
RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.
Function
This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases that contain SH2-like (Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins.
Clinical significance
The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.
Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in signal transduction downstream of the insulin receptor. Mice lacking Akt2 show worse outcome in breast cancer initaited by the large T antigen as well as the neu oncogene.
Interactions
AKT2 has been shown to interact with:
Podcasts:
Akt
ALBUMS
- Reverie released: 2005
Akt
ALBUMS
- Blemmebeya released: 2011
- Déntrokirtòs released: 2007
Akt
ALBUMS
- Não Wave: Brazilian Post Punk 1983-1988 released: 2005
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by Echt
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
-
by AKWID
Kleine Wolke Über Einem Französischen Mädchen
by: EchtSie ist nicht was sie glaubt zu sein
Der Engel unterm Heiligenschein
Sie weiß zu jedem Thema was zu sagen
Und stellt nur aus Höflichkeit dumme Fragen
Denn sie ist so ja oh ja sie ist sie ist
Ja denn sie ist schön geboren
Doch nur bis sie den Mund aufmacht
Denn sie ist häßlich wenn sie lacht
Ja ja sie kennt die ganze Welt
Doch fand nie das was ihr gefällt
Vielleicht wird sie`s schon morgen finden
Bis dahin wird sie weiter grinsen
Denn sie ist so ja oh ja sie ist sie ist
Ja denn sie ist schön geboren
Doch nur bis sie den Mund aufmacht
Sie ist so häßlich wenn sie lacht
Denn sie ist so ja oh ja sie ist sie ist
Ja denn sie ist schön geboren
Doch nur bis sie den Mund aufmacht
Sie ist so häßlich wenn sie lacht
Latest News for: akt
Nazi-Projekt BRD! Akte D offiziell #staatenlos.info
- 1