Papers by SOUMYADIP GHOSH
Journal of Applied Pharmaceutical Research
Journal of Applied Pharmaceutical Research
Deconvolution of a multi-component interaction network using systems chemistry
Journal of Systems Chemistry, 2010
We describe the stepwise construction of an 8-component self-sorted system (1 - 8) by the sequent... more We describe the stepwise construction of an 8-component self-sorted system (1 - 8) by the sequential addition of components. This process occurs via a large number of states (28 = 256) and even a larger number of pathways (8! = 40320). A pathway (5, 6, 7, 8, 4, 3, 2, then 1) that is self-sorted at every step along the way has been demonstrated experimentally. Another pathway (1, 8, 3, 5, 4, 7, 2, then 6) resembles a game of musical chairs and exhibits interesting shuttling of guest molecules among hosts. The majority of pathways - unlike the special ones described above - proceed through several non self-sorted states. We characterized the remainder of the 40320 pathways by simulation using Gepasi and describe the influence of concentration and binding constants on the fidelity of the self-sorting pathways.
Dynamic Combinatorial Chemistry
Journal of Drug Delivery and Therapeutics
Drugs targeting the colonic environment to treat various colonic diseases are the major challenge... more Drugs targeting the colonic environment to treat various colonic diseases are the major challenges recently. Various drugs are available in the markets to targeting to the colonic region to treat diseases but due to premature drug releases, target specificity, the low concentration at the target site with high adverse effects which increase patients’ compliance day by day. Satranidazole is a promising drug that is particularly targeting the colonic environment and can break down microorganism DNA to involve the treatment of several diseases such as inflammatory bowel diseases subdivided Ulcerative colitis, Crohn’s disease, amoebiasis, chronic diarrhea, and reduction of pain due to inflammation. Conventional drug delivery of Satranidazole has some disadvantages such as target specificity, high dosing frequency, low therapeutic efficacy, and high adverse effects that can be overcome through targeted drug delivery systems. Satranidazole is successfully showing the efficacy against aero...
Journal of Drug Delivery and Therapeutics
Drugs targeting the colonic environment to treat various colonic diseases are the major challenge... more Drugs targeting the colonic environment to treat various colonic diseases are the major challenges recently. Various drugs are available in the markets to targeting to the colonic region to treat diseases but due to premature drug releases, target specificity, the low concentration at the target site with high adverse effects which increase patients’ compliance day by day. Satranidazole is a promising drug that is particularly targeting the colonic environment and can break down microorganism DNA to involve the treatment of several diseases such as inflammatory bowel diseases subdivided Ulcerative colitis, Crohn’s disease, amoebiasis, chronic diarrhea, and reduction of pain due to inflammation. Conventional drug delivery of Satranidazole has some disadvantages such as target specificity, high dosing frequency, low therapeutic efficacy, and high adverse effects that can be overcome through targeted drug delivery systems. Satranidazole is successfully showing the efficacy against aero...
Journal of Applied Pharmaceutical Research
Drug delivery to the colonic region refers to the drug that should have to released in the coloni... more Drug delivery to the colonic region refers to the drug that should have to released in the colonic environment instead of released in the upper gastrointestinal tract. To reach the site-specificity of the local treatment of the colon such as amoebiasis, colorectal cancer, and inflammatory bowel disease the target-specific drug delivery played an important role. To the establishment of the target-specific drug delivery to the colon, the various approach that has been explored include pH-dependent polymer, time-dependent, and bacteria-dependent drug delivery approach. Nanotechnology has been gaining much more interest due to target specificity and enhancement of bioavailability and high loading capacity. In this review, oral nanoparticle formulation for colon targeting specifically inflammatory bowel disease and suitable drugs for useful treatment and future aspects of nanoparticle formulation with particular approaches to enhancement of drug stability in the gastric environment have ...
Journal of Applied Pharmaceutical Research, 2021
Drug delivery to the colonic region refers to the drug that should have to released in the coloni... more Drug delivery to the colonic region refers to the drug that should have to released in the colonic environment instead of released in the upper gastrointestinal tract. To reach the site-specificity of the local treatment of the colon such as amoebiasis, colorectal cancer, and inflammatory bowel disease the target-specific drug delivery played an important role. To the establishment of the target-specific drug delivery to the colon, the various approach that has been explored include pH-dependent polymer, timedependent, and bacteria-dependent drug delivery approach. Nanotechnology has been gaining much more interest due to target specificity and enhancement of bioavailability and high loading capacity. In this review, oral nanoparticle formulation for colon targeting specifically inflammatory bowel disease and suitable drugs for useful treatment and future aspects of nanoparticle formulation with particular approaches to enhancement of drug stability in the gastric environment have been covered.
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Papers by SOUMYADIP GHOSH