Università degli Studi di Firenze (University of Florence)
Internal Medicine
Proc. Nati. Acad. Sci. USA Vol. 88, pp. 4538-4542, May 1991 Immunology ... Allergen-and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production ... PAOLA PARRONCHI*,... more
IL-17A is associated with different asthma phenotypes as virus-associated or steroid-resistant asthma. Invariant natural killer T (iNKT) cells play an important role in the pathogenesis of asthma. The aim of the study was to evaluate the... more
Phenotypic markers, localization, functional activities, and mechanisms of action in vitro of CD4 + CD25 + T cells, purified from postnatal human thymuses, were investigated. These cells showed poor or no proliferation in mixed lymphocyte... more
In addition to T helper type 1 (Th1) and Th2 cells, Th17 cells are a third arm of effector CD4(+) T cells. Human Th17 cells express RORC and CD161 and originate from RORC-expressing CD161(+) precursors, which migrate to lymphoid tissue... more
T-cell clones generated from both CD4+CD25+ and CD8+CD25+ human thymocytes were assessed for their ability to suppress the proliferative response to allogeneic stimulation of type 1 T-helper (Th1) or type 2 T-helper (Th2) clones derived... more
The administration of biological agents is potentially affected by IgE-mediated infusion reactions. The aim of the study was to evaluate the utility of skin testing in patients who have experienced infliximab (IFX)-related reactions.... more
Polarized human type 1 and type 2 T helper cells not only produce different sets of cytokines, but they also preferentially express certain activation markers, such as lymphocyte activation gene-3 (LAG-3) and CD30, respectively. In this... more
We have previously shown that human Th17 lymphocytes are characterized by the selective expression of IL-23 receptor (IL-23R), CCR6, CD161, and the transcription factor retinoic acid-related orphan receptor C (RORC), and originate from a... more