PDGFB

PDGFB
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1PDG, 3MJG, 4HQU, 4HQX, 4QCI
Ідентифікатори
Символи	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B
Зовнішні ІД	OMIM: 190040 MGI: 97528 HomoloGene: 74303 GeneCards: PDGFB
Онтологія гена Молекулярна функція • protein homodimerization activity • protein heterodimerization activity • chemoattractant activity • platelet-derived growth factor receptor binding • platelet-derived growth factor binding • superoxide-generating NADPH oxidase activator activity • growth factor activity • identical protein binding • collagen binding • GO:0001948, GO:0016582 protein binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Клітинна компонента • platelet alpha granule lumen • цитоплазма • extracellular region • Golgi membrane • basolateral plasma membrane • cell surface • endoplasmic reticulum lumen • мембрана • GO:0005578 Позаклітинна матриця • міжклітинний простір • Golgi lumen • collagen-containing extracellular matrix Біологічний процес • activation of protein kinase B activity • positive regulation of DNA biosynthetic process • positive regulation of chemotaxis • cellular response to growth factor stimulus • positive regulation of protein tyrosine kinase activity • peptidyl-tyrosine phosphorylation • positive regulation of cell division • heart development • positive regulation of glomerular filtration • positive regulation of mitotic nuclear division • positive regulation of MAP kinase activity • positive regulation of metanephric mesenchymal cell migration • positive regulation of hyaluronan biosynthetic process • MAPK cascade • protein phosphorylation • positive regulation of glomerular mesangial cell proliferation • cellular response to mycophenolic acid • positive regulation of fibroblast proliferation • activation of protein kinase activity • multicellular organism development • positive regulation of protein autophosphorylation • positive regulation of reactive oxygen species metabolic process • reactive oxygen species metabolic process • GO:0045996 negative regulation of transcription, DNA-templated • protein kinase C signaling • metanephric glomerular mesangial cell development • negative regulation of phosphatidylinositol biosynthetic process • response to wounding • positive regulation of phosphatidylinositol 3-kinase activity • cell chemotaxis • positive regulation of ERK1 and ERK2 cascade • platelet degranulation • positive regulation of cell population proliferation • positive regulation of DNA replication • GO:1901313 positive regulation of gene expression • embryonic placenta development • paracrine signaling • monocyte chemotaxis • positive regulation of endothelial cell proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of calcium ion import • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0035404 peptidyl-serine phosphorylation • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • positive regulation of blood vessel endothelial cell migration • кровотворення • positive regulation of cell migration • positive regulation of peptidyl-tyrosine phosphorylation • extracellular matrix organization • negative regulation of protein binding • positive regulation of MAPK cascade • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of platelet activation • phosphatidylinositol phosphate biosynthetic process • positive regulation of vascular associated smooth muscle cell migration • positive chemotaxis • negative regulation of vascular associated smooth muscle cell differentiation • interleukin-18-mediated signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of gene expression • positive regulation of smooth muscle cell migration • positive regulation of smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell dedifferentiation • platelet-derived growth factor receptor signaling pathway • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of platelet-derived growth factor receptor-beta signaling pathway • regulation of signaling receptor activity • positive regulation of protein kinase B signaling Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	5155	18591
Ensembl	ENSG00000100311	ENSMUSG00000000489
UniProt	P01127	P31240
RefSeq (мРНК)	NM_033016 NM_002608	NM_011057
RefSeq (білок)	NP_002599 NP_148937	NP_035187
Локус (UCSC)	Хр. 22: 39.22 – 39.24 Mb	Хр. 15: 80 – 80.01 Mb
PubMed search
Вікідані
Див./Ред. для людей Див./Ред. для мишей

PDGFB (англ. Platelet derived growth factor subunit B) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 22-ї хромосоми. Довжина поліпептидного ланцюга білка становить 241 амінокислот, а молекулярна маса — 27 283.

Послідовність амінокислот

10		20		30		40		50
MNRCWALFLS		LCCYLRLVSA		EGDPIPEELY		EMLSDHSIRS		FDDLQRLLHG
DPGEEDGAEL		DLNMTRSHSG		GELESLARGR		RSLGSLTIAE		PAMIAECKTR
TEVFEISRRL		IDRTNANFLV		WPPCVEVQRC		SGCCNNRNVQ		CRPTQVQLRP
VQVRKIEIVR		KKPIFKKATV		TLEDHLACKC		ETVAAARPVT		RSPGGSQEQR
AKTPQTRVTI		RTVRVRRPPK		GKHRKFKHTH		DKTALKETLG		A

A: Аланін
C: Цистеїн
D: Аспарагінова кислота
E: Глутамінова кислота
F: Фенілаланін
G: Гліцин
H: Гістидин
I: Ізолейцин
K: Лізин
L: Лейцин
M: Метіонін
N: Аспарагін
P: Пролін
Q: Глутамін
R: Аргінін
S: Серин
T: Треонін
V: Валін
W: Триптофан

Y: Тирозин

Кодований геном білок за функціями належить до факторів росту, мітогенів, білків розвитку. Секретований назовні.

Література

• Collins T., Ginsburg D., Boss J.M., Orkin S.H., Pober J.S. (1985). Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Nature. 316: 748—750. PMID 4033772 DOI:10.1038/316748a0
• Ratner L., Josephs S.F., Jarrett R., Reitz M.S., Wong-Staal F. (1985). Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor. Nucleic Acids Res. 13: 5007—5018. PMID 2991848 DOI:10.1093/nar/13.14.5007
• Rao C.D., Igarashi H., Chiu I.-M., Robbins K.C., Aaronson S.A. (1986). Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit. Proc. Natl. Acad. Sci. U.S.A. 83: 2392—2396. PMID 3517869 DOI:10.1073/pnas.83.8.2392
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
• Dirks R.P.H., Onnekink C., Jansen H.J., de Jong A., Bloemers H.P.J. (1995). A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein. Nucleic Acids Res. 23: 2815—2822. PMID 7659502 DOI:10.1093/nar/23.15.2815
• Weich H.A., Sebald W., Schairer H.U., Hoppe J. (1986). The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain. FEBS Lett. 198: 344—348. PMID 3456904 DOI:10.1016/0014-5793(86)80433-1

Див. також

• Хромосома 22