Vesiculab

Exploring the molecular components and applications of marine bacterial extracellular vesicles: in this review article, Angela Casillo and collaborators at Università degli Studi di Napoli Federico II (UniNa) / University of Naples Federico II conducted an in-depth analysis of marine bacterial extracellular vesicles, examining their structure, composition, functions, and potential therapeutic applications https://lnkd.in/gX4S-xH6 Marine bacterial EVs, with their natural ability to deliver bioactive compounds and recent advancements in synthetic biology for customizing vesicle cargos, present a promising strategy for biotechnological applications and innovation. An article co-authored by Raffaele D’Amico, Rosa Lanzetta and Maria Michela Corsaro #extracellularvesicles #exosomes #OMVs #marinebacteria #Vesiculab

Bacteria trigger extracellular vesicle production to modulate aging physiology: in their latest work, Yun Deng, Georg Pohnert at Friedrich Schiller University Jena and collaborators characterised the recovery process of the bloom-forming diatom Coscinodiscus radiatus from starvation following nutrient influx. Rejuvenation occurs through extracellular vesicles that transport reactive oxygen species, oxylipins, and other harmful metabolites out of the aged cells, thus restoring their ability to proliferate https://lnkd.in/g26BsEDg Their research offers fresh insights into cellular aging and rejuvenation within complex microbial communities. An article co-authored by Ruyi Y., Veit Grabe, Thomas Sommermann, Markus Werner, Dr. Marine V., Christian Zerfaß, PhD and Oliver Werz #extracellularvesicles #exosomes #bacteria #metabolomics #Vesiculab

Engineering an exosome-based drug delivery system for synergistic cancer therapy: in this work, Xin Hua, Songqin Liu at Southeast University developed an exosome-based drug delivery system that combines miRNA-mediated autophagy inhibition with 7-coumarin chemotherapy for enhanced ovarian cancer treatment https://lnkd.in/ejEGR2tv They found that the engineered exosome-based drug delivery system enhanced drug uptake and improved targeting specificity towards cancer cells. An article co-authored by Yu Liu, Xi Liu, Qian Zhu, Sisi Zhou and Quan Li #extracellularvesicles #exosomes #bioengineering #ovariancancer #drugdelivery #Vesiculab

Investigating the role of small extracellular vesicles in oncoviral infections: in this review article, Łukasz Wazny, Monika Pietrowska at Maria Sklodowska-Curie National Research Institute of Oncology and Whiteside Theresa at UPMC Hillman Cancer Center provided a comprehensive overview of the current understanding of interactions between small extracellular vesicles and oncogenic viruses, emphasizing how sEVs can influence the carcinogenic properties of these viruses https://lnkd.in/eZnFtiGi They observed that there remains a significant gap in understanding the mechanisms governing the interactions between viruses, small extracellular vesicles, and cancer. They also suggested that future antiviral therapies could potentially target sEVs, which facilitate viral infections. #extracellularvesicles #exosomes #oncoviruses #viralinfection #Vesiculab

🚀 Exciting News! 🚀 We are thrilled to announce the appointment of Insungchromatech as Vesiculab's exclusive distributor in Korea! This partnership marks a significant milestone in our mission to bring innovation to extracellular vesicle and bio-nano research https://lnkd.in/ew-j6GiJ With Insungchromatech's expertise and dedication, the Korean research community is set to supercharge their research projects with Vesiculab solutions! #Vesiculab #Insungchromatech #NewPartnership #EVResearch #Korea #Innovation

Characterising extracellular vesicles in COVID-19 using flow cytometry: in this review article, Antonella Minutolo, Claudia Matteucci at University of Rome Tor Vergata and collaborators analysed the role of plasmatic EVs in COVID-19 patients and individuals with Long COVID affected by post-acute sequelae of SARS-CoV-2 infection, highlighting their dual function in exerting both pro- and antiviral effects https://lnkd.in/euV8SZ7V They also emphasised the utility of flow cytometry, with its multiparametric approach, for characterising circulating EVs, particularly in infectious diseases like COVID-19. An article co-authored by Marialaura Fanelli, Vita Petrone, Rossella Chirico and Claudia Maria Radu #extracellularvesicles #exosomes #biomarkers #flowcytometry #COVID19 #Vesiculab

Evaluating the therapeutic effect of cisplatin-encapsulated autologous iPSC-derived MSC extracellular vesicles: in their latest study, Caroline Küstermann at Latvian Biomedical Research & Study centre and collaborators aimed to demonstrate a proof-of-concept for using patient-specific organoid models of both lung cancer and normal lung tissue, highlighting the feasibility of employing autologous EVs derived from iPSC-MSCs in personalised medicine https://lnkd.in/eSYCCKE7 They noted that EV treatment had no significant effect on organoids, likely due to the insufficient quantity of EVs and the low encapsulated cisplatin dosage used. An article co-authored by Karīna Narbute, Valērija Movčana, Vadims Parfejevs, Fēlikss Rūmnieks, Pauls Kaukis, Miks Priedols, Rihards Mikilps Mikgelbs, Marija Mihailova, Santa Andersone, Aigars Dzalbs, Cristina Bajo, Alvils Krams and Arturs Abols #extracellularvesicles #exosomes #lungcancer #organoids #Vesiculab

In nano-flow cytometry, the detection of substrates such as extracellular vesicles, LNPs and viruses is very susceptible to the presence of unbound dye and antibody, as well as free proteins. Vesiculab's Vesi-SEC micro columns efficiently remove these impurities in just one minute, using a low-speed spin https://lnkd.in/etTuNX-p Net result: lower background, cleaner baseline, higher rate of events positive for fluorescence, lower risk of blocking capillaries Read Vesi-SEC micro user testimonials here: https://lnkd.in/ekARn85j #extracellularvesicles #exosomes #LNPs #viruses #flowcytometry #Vesiculab

Enhancing lymphatic vessel function with platelet extracellular vesicles: in their latest article, Laurent V., Catherine Martel at Université de Montréal and collaborators reported that platelet-derived extracellular vesicles in lymph possess a unique signature, allowing them to effectively interact with lymphatic endothelial cells https://lnkd.in/e8qDAsgK They observed that treating atherosclerosis-prone mice with platelet-derived EVs enhanced lymphatic contraction capacity and that boosting lymphatic function with exogenous platelet EVs could offer a novel therapeutic approach for chronic inflammatory diseases with defective lymphatics. An article co-auhored by Gabriel Jean, Andreea Milasan, PhD MBA, Sara Babran, Elizabeth Lacroix, Dainelys Guadarrama Bello, Louis Villeneuve, Janusz Rak, Antonio Nanci, Téodora Mihalache-Avram, Jean-Claude Tardif, Vincent Finnerty, Matthieu RUIZ, Eric Boilard and Nolwenn Tessier #extracellularvesicles #exosomes #atherosclerosis #flowcytometry #confocalmicroscopy #Vesiculab

Exploring exosomes as therapeutic and drug delivery vehicles for neurodegenerative diseases: in this review article, Zeynab Nouri, Fatemeh Atyabi at Tehran University of Medical Sciences and collaborators highlighted the potential of exosomes in treating neurodegenerative diseases, focusing on the relevant signaling pathways and molecular mechanisms involved https://lnkd.in/eX6rpZ3N They noted that although exosomes possess unique properties beneficial for neurodegenerative therapy, further advancements in surface modification are needed to enhance targeted delivery, bypass the blood-brain barrier, and achieve optimal biodistribution. An article also authored by Ashkan Barfar, Sahra Perseh, Hamidreza motasadizadeh, Samane Maghsoudian, Yousef Fatahi, keyvan nouri, Mohaddese Pourashory Yektakasmaei and Rassoul Dinarvand #extracellularvesicles #exosomes #neurodegenerativediseases #targeteddelivery #Vesiculab