Papers by M. Daniela Angione
ACS Applied Materials & Interfaces, 2015
Poly(ether sulfone) membranes (PES) were modified with biologically active monosaccharides and di... more Poly(ether sulfone) membranes (PES) were modified with biologically active monosaccharides and disaccharides using aryldiazonium chemistry as a mild, one-step, surface-modification strategy. We previously proposed the modification of carbon, metals, and alloys with monosaccharides using the same method; herein, we demonstrate modification of PES membranes and the effect of chemisorbed carbohydrate layers on their resistance to biofouling. Glycosylated PES surfaces were characterized using spectroscopic methods and tested against their ability to interact with specific carbohydrate-binding proteins. Galactose-, mannose-, and lactose-modified PES surfaces were exposed to Bovine Serum Albumin (BSA) solutions to assess unspecific protein adsorption in the laboratory and were found to adsorb significantly lower amounts of BSA compared to bare membranes. The ability of molecular carbohydrate layers to impart antifouling properties was further tested in the field via long-term immersive tests at a wastewater treatment plant. A combination of ATP content assays, infrared spectroscopic characterization and He-ion microscopy (HIM) imaging were used to investigate biomass accumulation at membranes. We show that, beyond laboratory applications and in the case of complex aqueous environments that are rich in biomass such as wastewater effluent, we observe significantly lower biofouling at carbohydrate-modified PES than at bare PES membrane surfaces.
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Organic Electronics, 2012
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Proceedings of the National Academy of Sciences, 2012
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2009 3rd International Workshop on Advances in sensors and Interfaces, 2009
A novel bottom-gate top-contact OTFT architecture has been fabricated. In this device, a lipid bi... more A novel bottom-gate top-contact OTFT architecture has been fabricated. In this device, a lipid bilayer structure embedding a photosynthetic membrane protein extracted from Rhodobacter Sphaeroides has been deposited onto the organic semiconductor film (alpha,omega-dihexylsexythiophene) prior to the evaporation of source and drain gold contacts. The figures of merit of this device were extracted and compared to those obtained for the
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Chemical Communications, 2010
The relations between the chemical-physical properties of novel designed monodispersed donors and... more The relations between the chemical-physical properties of novel designed monodispersed donors and their photovoltaic performances are discussed. The importance of intermolecular interactions is emphasized to figure out the achievement of high performing bulk hetero-junction solar cells which are solution processed.
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Organic thin-film transistors, used as sensing devices, have been attracting quite a considerable... more Organic thin-film transistors, used as sensing devices, have been attracting quite a considerable interest lately as they offer advantages such as multi parameter behaviour and possibility to be quite easily molecularly tuned for the detection of specific analytes. Here, a study on the dependences of the devices responses on important parameters such as the active layer thickness and its morphology
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2009 3rd International Workshop on Advances in sensors and Interfaces, 2009
A novel bottom-gate top-contact OTFT architecture has been fabricated. In this device, a lipid bi... more A novel bottom-gate top-contact OTFT architecture has been fabricated. In this device, a lipid bilayer structure embedding a photosynthetic membrane protein extracted from Rhodobacter Sphaeroides has been deposited onto the organic semiconductor film (alpha,omega-dihexylsexythiophene) prior to the evaporation of source and drain gold contacts. The figures of merit of this device were extracted and compared to those obtained for the
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Electrochimica Acta, 2011
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Organic thin film transistor (OTFT) technology can be implemented to develop cost-effective and l... more Organic thin film transistor (OTFT) technology can be implemented to develop cost-effective and label-free bio-affinity sensor chips, having a field-effect transport directly coupled to a bio-sensing process, useful to high-throughput testing and point-of-care applications. Biological recognition elements such as antibodies or other proteins can be integrated in OTFT devices to confer specificity. In this study the use of lipid bilayers as support for biomolecules immobilization is investigated. Preliminary results in terms of electrical resistance and capacitance of the lipid bilayers are presented.
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A novel bottom-gate top-contact OTFT architecture has been fabricated. In this device, a lipid bi... more A novel bottom-gate top-contact OTFT architecture has been fabricated. In this device, a lipid bilayer structure embedding a photosynthetic membrane protein extracted from Rhodobacter Sphaeroides has been deposited onto the organic semiconductor film (alpha,omega-dihexylsexythiophene) prior to the evaporation of source and drain gold contacts. The figures of merit of this device were extracted and compared to those obtained for the same OTFT devoid of the biological film. Only slightly lower performances in terms of field-effect mobility (mu) were observed for the lipid bilayer OTFT that exhibits mu = 0.007 cm2/Vs. This result constitutes a preliminary important starting point towards the development of novel highly sensitive and selective herbicides sensors.
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Chemical Communications, 2010
The relations between the chemical-physical properties of novel designed monodispersed donors and... more The relations between the chemical-physical properties of novel designed monodispersed donors and their photovoltaic performances are discussed. The importance of intermolecular interactions is emphasized to figure out the achievement of high performing bulk hetero-junction solar cells which are solution processed.
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Electrochimica Acta, 2011
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Materials Today, 2011
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Organic thin-film transistors, used as sensing devices, have been attracting quite a considerable... more Organic thin-film transistors, used as sensing devices, have been attracting quite a considerable interest lately as they offer advantages such as multi parameter behaviour and possibility to be quite easily molecularly tuned for the detection of specific analytes. Here, a study on the dependences of the devices responses on important parameters such as the active layer thickness and its morphology as well as on the transistor channel length is presented. To introduce the least number of variables the system chosen for this study is quite a simple and well assessed one being based on a thiophene oligomer active layer exposed to 1-butanol vapours.
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To satisfy the demand for fast and smart analytical systems a great interest has been focused on ... more To satisfy the demand for fast and smart analytical systems a great interest has been focused on the study and development of novel bio-sensing devices. Electronic transduction can open new perspectives for point-of-care diagnosis actuated by fast, sensitive, selective and reliable biosensors. Recently our group demonstrated the feasibility of the coupling of a biological recognition element to an organic field-effect device [3, 4]. As a further step, investigations on different deposition techniques have been developed, to improve the adhesion and the homogeneity of the biological element onto the organic semiconductor.
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Papers by M. Daniela Angione