Tropomiozinska receptorska kinaza C

NTRK3
Available structures PDB Pretraga ortologa: PDBe RCSB List of PDB id codes 1WWC, 3V5Q, 4YMJ
Identifikatori
Alijasi	NTRK3
Spoljašnji ID	OMIM: 191316 MGI: 97385 HomoloGene: 49183 GeneCards: NTRK3
Genska lokacija (miš) Hr. Chromosome 7 (mouse) Band 7 D2|7 44.01 cM Start 78,175,959 bp Kraj 78,738,012 bp
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • nucleotide binding • protein tyrosine kinase activity • neurotrophin binding • protein kinase activity • transferase activity • transmembrane receptor protein tyrosine kinase activity • kinase activity • neurotrophin receptor activity • GPI-linked ephrin receptor activity • ATP binding • p53 binding • GO:0001948, GO:0016582 везивање за протеине плазме • Receptor tirozinska kinaza • transmembrane signaling receptor activity Cellular component • цитоплазма • саставни део мембране • мембрана • receptor complex • integral component of plasma membrane • ћелијска мембрана • glutamatergic synapse • integral component of postsynaptic membrane • аксон Biological process • биолошки часовник • positive regulation of peptidyl-serine phosphorylation • ephrin receptor signaling pathway • реакција на етанол • activation of protein kinase B activity • positive regulation of synapse assembly • multicellular organism development • positive regulation of actin cytoskeleton reorganization • positive regulation of cell migration • response to corticosterone • protein autophosphorylation • negative regulation of cell death • heart development • positive regulation of apoptotic process • peptidyl-tyrosine phosphorylation • cochlea development • ментални развој • GO:1901313 positive regulation of gene expression • GO:0033128 negative regulation of protein phosphorylation • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • protein phosphorylation • neurotrophin signaling pathway • cellular response to retinoic acid • neuron fate specification • positive regulation of axon extension involved in regeneration • positive regulation of cell population proliferation • modulation by virus of host transcription • lens fiber cell differentiation • mechanoreceptor differentiation • response to axon injury • positive regulation of positive chemotaxis • диференцијација • negative regulation of astrocyte differentiation • positive regulation of protein phosphorylation • neuron migration • Fosforilacija • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of phospholipase C activity • positive regulation of phosphatidylinositol 3-kinase signaling • regulation of postsynaptic density assembly • regulation of presynapse assembly • negative regulation of signal transduction • positive regulation of neuron projection development • neuronal action potential propagation • myelination in peripheral nervous system • негативно регулисање апоптотичког процеса • positive regulation of ERK1 and ERK2 cascade • cellular response to nerve growth factor stimulus • regulation of MAPK cascade • positive regulation of MAPK cascade • positive regulation of neurotrophin TRK receptor signaling pathway Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	4916	18213
Ensembl	ENSG00000140538	ENSMUSG00000059146
UniProt	Q16288	Q6VNS1
RefSeq (mRNA)	NM_001007156 NM_001012338 NM_001243101 NM_002530 NM_001320134 NM_001320135 NM_001375810 NM_001375811 NM_001375812 NM_001375813 NM_001375814	NM_008746 NM_182809
RefSeq (protein)	NP_001007157 NP_001012338 NP_001230030 NP_001307063 NP_001307064 NP_002521 NP_001362739 NP_001362740 NP_001362741 NP_001362742 NP_001362743 NP_002521.2	NP_032772 NP_877961
Location (UCSC)	n/a	Chr 7: 78.18 – 78.74 Mb
PubMed search
Wikidata
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Receptor NT-3 faktora rasta (neurotrono tirozinsko kinazni receptor tip 3, TrkC tirozinska kinaza, Trk-C receptor) protein protein je koji je kod ljudi kodiran NTRK3 genom.

TrkC je katalitički receptor sa visokim afinitetom za neurotrofin NT-3 (neurotrofin-3). Kao takav, TrkC posreduje višestruke efekte ovog neurotrofnog faktora, među kojima je neuronska diferencijacija i opstanak.

TrkC receptor je deo velike familije receptorskih tirozinskih kinaza. "Tirozinske kinaze" su enzimi koji imaju sposobnost dodavanja fosfatne grupe na pojedine tirozine na ciljnim proteinima, ili "supstratima". Receptorske tirozinske kinaze su "tirozinske kinaze kojesu locirane na ćelijskim membranama, i koje se aktiviraju vezivanjem liganda za njihove ekstracelularne domene.

Literatura

• Lamballe F, Klein R, Barbacid M (1991). „trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3”. Cell. 66 (5): 967—79. PMID 1653651. doi:10.1016/0092-8674(91)90442-2. 
• Tessarollo L, Tsoulfas P, Martin-Zanca D, Gilbert DJ, Jenkins NA, Copeland NG, Parada LF (1993). „trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues”. Development. 118 (2): 463—75. PMID 8223273. 
• Klein R, Silos-Santiago I, Smeyne RJ, Lira SA, Brambilla R, Bryant S, Zhang L, Snider WD, Barbacid M (1994). „Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements”. Nature. 368 (6468): 249—51. PMID 8145824. doi:10.1038/368249a0. 
• Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, Greene LA, Barbacid M, Yancopoulos GD (1993). „Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells”. Neuron. 10 (2): 137—49. PMID 7679912. doi:10.1016/0896-6273(93)90306-C. 
• Ebendal T (1992). „Function and evolution in the NGF family and its receptors”. Journal of Neuroscience Research. 32 (4): 461—70. PMID 1326636. doi:10.1002/jnr.490320402. 
• Guiton M, Gunn-Moore FJ, Glass DJ, Geis DR, Yancopoulos GD, Tavaré JM (1995). „Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling”. The Journal of Biological Chemistry. 270 (35): 20384—90. PMID 7657612. doi:10.1074/jbc.270.35.20384. 
• Shelton DL, Sutherland J, Gripp J, Camerato T, Armanini MP, Phillips HS, Carroll K, Spencer SD, Levinson AD (1995). „Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins”. The Journal of Neuroscience. 15 (1 Pt 2): 477—91. PMID 7823156. 
• Pflug BR, Dionne C, Kaplan DR, Lynch J, Djakiew D (1995). „Expression of a Trk high affinity nerve growth factor receptor in the human prostate”. Endocrinology. 136 (1): 262—8. PMID 7828539. doi:10.1210/en.136.1.262. 
• Lamballe F, Tapley P, Barbacid M (1993). „trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities”. The EMBO Journal. 12 (8): 3083—94. PMC 413573 . PMID 8344249. 
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). „A "double adaptor" method for improved shotgun library construction”. Analytical Biochemistry. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138. 
• Yamamoto M, Sobue G, Yamamoto K, Terao S, Mitsuma T (1996). „Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues”. Neurochemical Research. 21 (8): 929—38. PMID 8895847. doi:10.1007/BF02532343. 
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). „Large-scale concatenation cDNA sequencing”. Genome Research. 7 (4): 353—8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353. 
• Valent A, Danglot G, Bernheim A (1997). „Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization”. European Journal of Human Genetics. 5 (2): 102—4. PMID 9195161. 
• Terenghi G, Mann D, Kopelman PG, Anand P (1997). „trkA and trkC expression is increased in human diabetic skin”. Neuroscience Letters. 228 (1): 33—6. PMID 9197281. doi:10.1016/S0304-3940(97)00350-9. 
• Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). „A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma”. Nature Genetics. 18 (2): 184—7. PMID 9462753. doi:10.1038/ng0298-184. 
• Urfer R, Tsoulfas P, O'Connell L, Hongo JA, Zhao W, Presta LG (1998). „High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors”. The Journal of Biological Chemistry. 273 (10): 5829—40. PMID 9488719. doi:10.1074/jbc.273.10.5829. 
• Hu YQ, Koo PH (1998). „Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin”. Journal of Neurochemistry. 71 (1): 213—20. PMID 9648868. doi:10.1046/j.1471-4159.1998.71010213.x. 
• Ichaso N, Rodriguez RE, Martin-Zanca D, Gonzalez-Sarmiento R (1998). „Genomic characterization of the human trkC gene”. Oncogene. 17 (14): 1871—5. PMID 9778053. doi:10.1038/sj.onc.1202100. 
• Qian X, Riccio A, Zhang Y, Ginty DD (1998). „Identification and characterization of novel substrates of Trk receptors in developing neurons”. Neuron. 21 (5): 1017—29. PMID 9856458. doi:10.1016/S0896-6273(00)80620-0. 
• Bibel M, Hoppe E, Barde YA (1999). „Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR”. The EMBO Journal. 18 (3): 616—22. PMC 1171154 . PMID 9927421. doi:10.1093/emboj/18.3.616. 
• Labouyrie E, Dubus P, Groppi A, Mahon FX, Ferrer J, Parrens M, Reiffers J, de Mascarel A, Merlio JP (1999). „Expression of neurotrophins and their receptors in human bone marrow”. The American Journal of Pathology. 154 (2): 405—15. PMC 1849993 . PMID 10027399. doi:10.1016/s0002-9440(10)65287-x.