Pirimetamin

Pirimetamin
IUPAC ime
	5-(4-hlorofenil)-6-etilpirimidin-2,4-diamin
Klinički podaci
Prodajno ime	Darachlor, Daraclor, Darapram, Daraprim
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	96 sata
Identifikatori
CAS broj	58-14-0
ATC kod	P01BD01 (WHO)
PubChem	CID 4993
DrugBank	DB00205
ChemSpider	4819
KEGG	C07391
ChEMBL	CHEMBL8673
Hemijski podaci
Formula	C12H13ClN4
Molarna masa	248.711
	SMILES CCC1=C(C(N)=NC(N)=N1)C1=CC=C(Cl)C=C1; ;
	InChI InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17) ; Key:WKSAUQYGYAYLPV-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	2.335 °C (4.235 °F)

Pirometamin je jedan od antagonista folne kiseline koji se koristi kao antimalarijalni agens ili sa sulfonamidom za tretma toksoplazmoze.^[1]^[2]^[3]^[4]

Reference

^ Gatton, M. L.; Martin, L. B.; Cheng, Q. (јун 2004). „Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum”. Antimicrobial Agents and Chemotherapy. 48 (6): 2116—23. PMC 415611 . PMID 15155209. doi:10.1128/AAC.48.6.2116-2123.2004.
^ Sirichaiwat, C.; Intaraudom, C.; Kamchonwongpaisan, S.; Vanichtanankul, J.; Thebtaranonth, Y.; Yuthavong, Y. (јануар 2004). „Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: Their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum”. Journal of Medicinal Chemistry. 47 (2): 345—54. PMID 14711307. doi:10.1021/jm0303352.
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

Spoljašnje veze

Pyrimethamine

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Gatton, M. L.; Martin, L. B.; Cheng, Q. (јун 2004). „Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum”. Antimicrobial Agents and Chemotherapy. 48 (6): 2116—23. PMC 415611 . PMID 15155209. doi:10.1128/AAC.48.6.2116-2123.2004.

[2] Sirichaiwat, C.; Intaraudom, C.; Kamchonwongpaisan, S.; Vanichtanankul, J.; Thebtaranonth, Y.; Yuthavong, Y. (јануар 2004). „Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: Their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum”. Journal of Medicinal Chemistry. 47 (2): 345—54. PMID 14711307. doi:10.1021/jm0303352.

[3] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[4] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

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